3-Oxopentadecanoic acid methyl ester

Base Information

• Chemical Name: 3-Oxopentadecanoic acid methyl ester
• CAS No.: 54889-72-4
• Molecular Formula: C16H30O3
• Molecular Weight: 270.412
• Hs Code.: 2918300090
• Mol file: 54889-72-4.mol

Synonyms:3-Oxopentadecanoic acid methyl ester

Chemical Property of 3-Oxopentadecanoic acid methyl ester

Chemical Property:

• PSA: 43.37000
• LogP: 4.42960

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Oxopentadecanoic acid methyl ester

There total 5 articles about 3-Oxopentadecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

bromoundecane (693-67-4) + acetoacetic acid methyl ester (105-45-3) → methyl 3-oxopentadecanoate (54889-72-4)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(01)00483-X

Reference yield:

methanol (67-56-1) + 5-(1-Hydroxytridecylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione → methyl 3-oxopentadecanoate (54889-72-4)

Guidance literature:

for 3h; Reflux;

DOI:10.1016/j.tet.2016.12.040

Reference yield:

tridecanoic acid (638-53-9) → methyl 3-oxopentadecanoate (54889-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: 3 h / Reflux

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/j.tet.2016.12.040

upstream raw materials:

n-tridecanoyl chloride

sodium ethyl acetylacetate enolate

bromoundecane

acetoacetic acid methyl ester

Downstream raw materials:

3-hydroxypentadecanoic acid