METHYL 4-METHOXY-[7-13C]-BENZOATE

Base Information

• Chemical Name: METHYL 4-METHOXY-[7-13C]-BENZOATE
• CAS No.: 93627-95-3
• Molecular Formula: C9H10O3
• Molecular Weight: 167.166
• Mol file: 93627-95-3.mol

Synonyms:METHYL 4-METHOXY-[7-13C]-BENZOATE;4-Methoxy-benzoic-carboxy-13C Acid Methyl Ester

Chemical Property of METHYL 4-METHOXY-[7-13C]-BENZOATE

Chemical Property:

• PSA: 35.53000
• LogP: 1.48180
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

Methyl 4-Methoxy-[7-13C]-benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-Methoxy-[7-13C]-benzoate (cas# 93627-95-3) is a compound useful in organic synthesis.

Technology Process of METHYL 4-METHOXY-[7-13C]-BENZOATE

There total 2 articles about METHYL 4-METHOXY-[7-13C]-BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 1-bromo-4-methoxy-benzene (104-92-7) + [13C]-formaldehyde (3228-27-1,89277-65-6) → methyl 4-methoxy-<7-13C>benzoate (93627-95-3)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); sodium carbonate; magnesium sulfate; 1,4-di(diphenylphosphino)-butane; at 120 ℃; for 20h; Inert atmosphere;

DOI:10.1002/anie.201404833

Reference yield:

4-methoxy-<7-13C>benzoic acid (69838-89-7) + methyl iodide (74-88-4) → methyl 4-methoxy-<7-13C>benzoate (93627-95-3)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Heating;

DOI:10.1021/ja00079a009

Reference yield:

methyl 4-methoxy-<7-13C>benzoate (93627-95-3) → 4-methoxy-<7-13C>benzyl alcohol (76104-36-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Yield given; Heating;

DOI:10.1021/ja00079a009

upstream raw materials:

4-methoxy-<7-13C>benzoic acid

methyl iodide

methanol

1-bromo-4-methoxy-benzene

Downstream raw materials:

4-methoxy-<7-13C>benzyl alcohol

α-[¹³C]-4-methoxybenzaldehyde

4-hydroxy-<7-13C>benzaldehyde

4-hydroxy-<7-13C,7-2H>benzaldehyde

Refernces

• 1、 Cho,Beale,Graff,Mocek,Nakagawa,Omura,Floss. "Studies on the biosynthesis of the antibiotic reductiomycin in Streptomyces xanthochromogenus". . p. 12296 - 12304. Retrieved 2007/10/02.