2-Fluoro-4-iodonicotinonitrile

Base Information

• Chemical Name: 2-Fluoro-4-iodonicotinonitrile
• CAS No.: 898854-59-6
• Molecular Formula: C₆H₂FIN₂
• Molecular Weight: 247.998
• Mol file: 898854-59-6.mol

Synonyms:2-Fluoro-4-iodonicotinonitrile

Chemical Property of 2-Fluoro-4-iodonicotinonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 1.69698
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-4-iodonicotinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-4-iodonicotinonitrile

There total 2 articles about 2-Fluoro-4-iodonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-cyano-2-fluoropyridine (3939-13-7) → 2-fluoro-4-iodonicotinonitrile (898854-59-6)

Guidance literature:

3-cyano-2-fluoropyridine; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at -70 ℃; for 1h; Inert atmosphere;

With iodine; In tetrahydrofuran; at 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02572

Reference yield:

P-toluenesulfonyl cyanide (19158-51-1) + 2-fluoro-3-iodopyridine (113975-22-7) → 2-fluoro-4-iodonicotinonitrile (898854-59-6) + 2-fluoro-3-iodoisonicotinonitrile (898854-64-3)

Guidance literature:

2-fluoro-3-iodopyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -75 ℃; for 1.16667h;

P-toluenesulfonyl cyanide; In tetrahydrofuran; at -75 ℃; for 2h;

upstream raw materials:

P-toluenesulfonyl cyanide

2-fluoro-3-iodopyridine

3-cyano-2-fluoropyridine

Refernces

• 1、 -. "SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE". Page/Page column 12. . Retrieved 2010/11/30.