1H-Pyrazole-5-carboxylicacid,3-methoxy-1-methyl-(9CI)

Base Information

• Chemical Name: 1H-Pyrazole-5-carboxylicacid,3-methoxy-1-methyl-(9CI)
• CAS No.: 126674-95-1
• Molecular Formula: C6H8N2O3
• Molecular Weight: 156.14
• Hs Code.: 2933199090
• Mol file: 126674-95-1.mol

Synonyms:1H-Pyrazole-5-carboxylicacid,3-methoxy-1-methyl-(9CI);1H-PYRAZOLE-5-CARBOXYLIC ACID, 3-METHOXY-1-METHYL-;3-Methoxy-1-Methyl-1H-pyrazole-5-carboxylic acid;1-Methyl-3-methoxypyrazole-5-carboxylic acid

Chemical Property of 1H-Pyrazole-5-carboxylicacid,3-methoxy-1-methyl-(9CI)

Chemical Property:

• Boiling Point: 343.4±22.0 °C(Predicted)
• PKA: 2.90±0.25(Predicted)
• PSA: 64.35000
• Density: 1.35±0.1 g/cm3(Predicted)
• LogP: 0.12690
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-1-methyl-1H-pyrazole-5-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-5-carboxylicacid,3-methoxy-1-methyl-(9CI)

There total 2 articles about 1H-Pyrazole-5-carboxylicacid,3-methoxy-1-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 3-methoxy-1-methyl-1H-pyrazole-5-carboxylate (55781-86-7) → 5-methoxy-2-methylpyrazole-3-carboxylic acid (126674-95-1)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 5h;

Reference yield:

5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (52867-42-2) → 5-methoxy-2-methylpyrazole-3-carboxylic acid (126674-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: sodium hydroxide; water / methanol / 5 h / 20 °C

With water; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield: 85.0%

oxalyl dichloride (79-37-8) + 5-methoxy-2-methylpyrazole-3-carboxylic acid (126674-95-1) + N-[6-(3-amino-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (1005780-53-9) → N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-3-methoxy-1-methyl-1H-pyrazole-5-carboxamide (1005785-39-6)

Guidance literature:

In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

upstream raw materials:

methyl 3-methoxy-1-methyl-1H-pyrazole-5-carboxylate

5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester

Downstream raw materials:

N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-3-methoxy-1-methyl-1H-pyrazole-5-carboxamide

N-[2-chloro-5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxy-1-methyl-1H-pyrazole-5-carboxamide

3-methoxy-1-methyl-N-{2-methyl-5-[(2-{[(2-methylcyclopropyl)carbonyl]amino}imidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-1H-pyrazole-5-carboxamide

N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-3-methoxy-1-methyl-1H-pyrazole-5-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 126674-95-1 1H-Pyrazole-5-carboxylicacid,3-methoxy-1-methyl-(9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send