BIA10-2474

Base Information

• Chemical Name: BIA10-2474
• CAS No.: 1233855-46-3
• Molecular Formula: C16H20N4O2
• Molecular Weight: 300.36
• Mol file: 1233855-46-3.mol

Synonyms:BIA10-2474

Chemical Property of BIA10-2474

Chemical Property:

• PSA: 63.59000
• LogP: 3.21120

Purity/Quality:

99.3% ^*data from raw suppliers

N-Cyclohexyl-N-methyl-4-(1-oxido-3-pyridinyl)-1H-imidazole-1-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Cyclohexyl-N-methyl-4-(1-oxido-3-pyridinyl)-1H-imidazole-1-carboxamide is a potential fatty acid amide hydrolase (FAAH) inhibitor used for treating and preventing diseases.

Technology Process of BIA10-2474

There total 12 articles about BIA10-2474 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-cyclohexyl-N-methyl-4-(pyridin-3-yl)-1H-imidazole-1-carboxamide (1233855-18-9) → 3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide (1233855-46-3)

Guidance literature:

N-cyclohexyl-N-methyl-4-(pyridin-3-yl)-1H-imidazole-1-carboxamide; With peracetic acid; In dichloromethane; at 25 ℃;

With sodium metabisulfite; In dichloromethane; water; at 30 ℃; Product distribution / selectivity;

Reference yield:

3-(1H-imidazol-4-yl)pyridine (51746-85-1) → 3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide (1233855-46-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 2 - 2.5 h / 25 °C

2.1: tetrahydrofuran / 19.5 h / 25 °C

3.1: peracetic acid / dichloromethane / 25 °C

3.2: 30 °C

With pyridine; peracetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

1-(pyridin-3-yl)ethan-1-one oxime (5973-83-1) → 3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide (1233855-46-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine / 5 - 25 °C

1.2: 10 - 25 °C

1.3: 3 h / 80 °C

2.1: water / 15 - 90 °C

3.1: sodium nitrite; nitric acid / water / 5 - 35 °C

4.1: pyridine / dichloromethane / 25 - 90 °C

5.1: peracetic acid / dichloromethane / 20 h / 25 °C

With pyridine; peracetic acid; nitric acid; sodium nitrite; In dichloromethane; water; 1.1: |Neber Rearrangement / 1.2: |Neber Rearrangement;

upstream raw materials:

3-(1H-imidazol-4-yl)pyridine

N-cyclohexyl-N-methyl-4-(pyridin-3-yl)-1H-imidazole-1-carboxamide

C₁₅H₁₁N₃O₂

N-methyl-N-cyclohexylaminocarbonyl chloride

Refernces

• 1、 -. "PROCESS FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS". . . Retrieved 2014/02/16.
• 2、 -. "PHARMACEUTICAL COMPOUNDS". Page/Page column 32. . Retrieved 2012/03/27.