5973-83-1

Basic information

• Product Name: 1-(3-PYRIDYL)ETHAN-1-ONE OXIME
• Synonyms: 3-acetylpyridineoxime;ketone,methyl3-pyridyl,oxime;1-PYRIDIN-3-YL-ETHANONE OXIME;1-(3-PYRIDYL)ETHAN-1-ONE OXIME;1-(3-pyridinyl)-1-ethanone oxime;1-(Pyridine-3-yl)ethanone oxime;3-Pyridyl(methyl) ketone oxime;Methyl pyridin-3-yl ketoxime
• CAS NO: 5973-83-1
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15
• Product Categories: pharmacetical
• Mol File: 5973-83-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 103 °C
• Boiling Point: 277.1 °C at 760 mmHg
• Flash Point: 121.4 °C
• Appearance: /
• Density: 1.11 g/cm³
• Vapor Pressure: 0.00222mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-(3-PYRIDYL)ETHAN-1-ONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-PYRIDYL)ETHAN-1-ONE OXIME(5973-83-1)
• EPA Substance Registry System: 1-(3-PYRIDYL)ETHAN-1-ONE OXIME(5973-83-1)

Safety Data

• RTECS: OB5600000
• HazardClass: IRRITANT
• Hazardous Substances Data: 5973-83-1(Hazardous Substances Data)

Usage

General Description

1-(3-Pyridyl)ethan-1-one oxime, also known as nicotine oxime, is a chemical compound that is commonly used in the synthesis of various pharmaceuticals, pesticides, and other organic compounds. It is an oxime derivative of nicotine, which is a highly addictive stimulant found in tobacco. The compound has been studied for its potential use as a chelating agent for heavy metal detoxification, as well as a potential treatment for nicotine addiction. It is also used as a screening tool in detection of cholinesterase inhibiting agents. Additionally, it has been investigated for its potential role in protecting against neurotoxicity associated with organophosphate compounds. Overall, 1-(3-Pyridyl)ethan-1-one oxime has a wide range of potential applications in the fields of medicine, agriculture, and environmental science.

InChI:InChI=1/C7H8N2O/c1-6(9-10)7-3-2-4-8-5-7/h2-5,10H,1H3/b9-6+

Upstream product

• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 1350770-35-2 C₁₇H₁₆N₂ 
• 1350770-34-1 6-ethyl-3-methyl-5-phenyl-1,4-naphthyridine 
• 93103-29-8 4-(pyridin-3-yl)-1H-imidazole-2(3H)-thione 
• 51746-85-1 3-(1H-imidazol-4-yl)pyridine 
• 1233855-18-9 N-cyclohexyl-N-methyl-4-(pyridin-3-yl)-1H-imidazole-1-carboxamide 
• 1233855-46-3 3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide 
• 1356960-88-7 C₁₅H₁₁N₃O₂ 
• 1356960-60-5 N-benzyl-N-methyl-4-(pyridin-3-yl)-1H-imidazole-1-carboxamide 
• 51746-82-8 2-amino-1-pyridin-3-yl-ethanone dihydrochloride salt 
• 56129-55-6 1-pyridin-3-yl-ethylamine 
• 136469-80-2 bis-(1-[3]pyridyl-ethyl)-amine 
• 51941-15-2 3-(α-aminoacetyl)pyridine 
• 93103-29-8 4-Pyridin-3-yl-1H-imidazole-2-thiol 
• 173838-67-0 4-(3-pyridyl)-1H-imidazol-1-butanamide phthalimide 

Relevant articles and documents

Beckmann rearrangement of ketoximes promoted by cyanuric chloride and dimethyl sulfoxide under a mild condition

Synthesis of amides via Beckmann rearrangement of ketoximes promoted by cyanuric chloride (TCT)/DMSO under mild conditions has been reported. Conditions of the Beckmann rearrangement, e.g., solvents, the ratios of TCT/DMSO, and the temperature, were investigated using diphenylmethanone oxime as a substrate. The optimized conditions were adopted to afford fourteen amides with yields ranging from 20% to 99%. A plausible mechanism involving an active dimethyl alkoxysulfonium intermediate was proposed according to the mass spectrometry analysis. To our best knowledge, this is the first case of study on Beckmann rearrangement of ketoximes promoted by TCT/DMSO under a mild condition to afford amides efficiently.

Synthesis and Antibacterial Activity of Novel 4″-O-desosaminyl clarithromycin derivatives with 11, 12-arylalkyl side chains

A series of novel 4″-O-desosaminyl clarithromycin derivatives with 11, 12-arylalkyl side chains was synthesized by coupling 6-deoxy-desosamine donors (18, 19) with 4″-OH of compounds 5a–c. The activities of the target compounds were tested against a series of macrolide-sensitive and macrolide-resistant pathogens. Some of them showed activities against macrolide sensitive and resistant pathogens, and compounds 21d and 21e displayed significant improvement of activities against resistant pathogens.

Catalytic Enantio- and Diastereoselective Mannich Addition of TosMIC to Ketimines

Chiral amines bearing a stereocenter in the α position are ubiquitous compounds with many applications in the pharmaceutical and agrochemical sectors, as well as in catalysis. Catalytic asymmetric Mannich additions represent a valuable method to access such compounds in enantioenriched form. This work reports the first enantio- and diastereoselective addition of commercially available p-toluenesulfonylmethyl isocyanide (TosMIC) to ketimines, affording 2-imidazolines bearing two contiguous stereocenters, one of which is fully-substituted, with high yields and excellent stereocontrol. The reaction, catalyzed by silver oxide and a dihydroquinine-derived N,P-ligand, is broad in scope, operationally simple, and scalable. Derivatization of the products provides enantioenriched vicinal diamines, precursors to NHC ligands and sp3-rich heterocyclic scaffolds. Computations are used to understand catalysis and rationalize stereoselectivity.