Benzoic acid, 2-[(3,5,6-trimethyl-2-pyrazinyl)methoxy]-, ethyl ester

Base Information

• Chemical Name: Benzoic acid, 2-[(3,5,6-trimethyl-2-pyrazinyl)methoxy]-, ethyl ester
• CAS No.: 947243-90-5
• Molecular Formula: C17H20N2O3
• Molecular Weight: 0
• Mol file: 947243-90-5.mol

Synonyms:Benzoic acid, 2-[(3,5,6-trimethyl-2-pyrazinyl)methoxy]-, ethyl ester

Chemical Property of Benzoic acid, 2-[(3,5,6-trimethyl-2-pyrazinyl)methoxy]-, ethyl ester

Chemical Property:

• Melting Point: 64 - 68 °C (hexane)
• PSA: 61.31000
• LogP: 3.15750

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 2-[(3,5,6-trimethyl-2-pyrazinyl)methoxy]-, ethyl ester

There total 3 articles about Benzoic acid, 2-[(3,5,6-trimethyl-2-pyrazinyl)methoxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(chloromethyl)-3,5,6-trimethylpyrazine (123624-90-8) + 2-hydroxy-benzoic acid ethyl ester (118-61-6) → ethyl 2-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (947243-90-5)

Guidance literature:

2-hydroxy-benzoic acid ethyl ester; With tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 0.166667h;

2-(chloromethyl)-3,5,6-trimethylpyrazine; In N,N-dimethyl-formamide; at 60 ℃; for 6h;

DOI:10.1039/c3md20352b

Reference yield: 50.0%

2-(bromomethyl)-3,5,6-trimethylpyrazine (79074-45-6) + 2-hydroxy-benzoic acid ethyl ester (118-61-6) → ethyl 2-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (947243-90-5)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 2h;

DOI:10.1002/cbdv.200900353

Reference yield:

salicylic acid (69-72-7,25496-36-0,8052-31-1) → ethyl 2-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (947243-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 24 h / Reflux

2.1: potassium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 0.17 h / 25 °C

2.2: 6 h / 60 °C

With thionyl chloride; tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1039/c3md20352b

upstream raw materials:

2-(bromomethyl)-3,5,6-trimethylpyrazine

2-hydroxy-benzoic acid ethyl ester

salicylic acid

2-(chloromethyl)-3,5,6-trimethylpyrazine

Downstream raw materials:

N-(diaminomethylidene)-2-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzamide hydrochloride

C₁₆H₁₉N₅O₂

Refernces

• 1、 Ren, Mei,Dong, Jin,Xu, Yungen,Wen, Nan,Gong, Guoqing. "Synthesis of novel ligustrazine derivatives as Na+/H+ exchange inhibitors". experimental part. p. 2727 - 2736. Retrieved 2011/08/06.