(4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenylthio)methyl acetate

Base Information

Chemical Name:(4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenylthio)methyl acetate
CAS No.:641640-05-3
Molecular Formula:C₂₈H₄₂N₂O₄SSi
Molecular Weight:530.804
Hs Code.:

Synonyms:(4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenylthio)methyl acetate

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Chemical Property of (4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenylthio)methyl acetate

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Technology Process of (4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenylthio)methyl acetate

There total 6 articles about (4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenylthio)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 108-24-7
acetic anhydride

: 641640-04-2
1-{1-cyclohexyl-5-[4-(methylsulfinyl)phenyl]pyrazol-3-yl}-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

: 641640-05-3
(4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenylthio)methyl acetate

Guidance literature:: With sodium acetate; for 8h; Heating;
DOI:10.1021/jm030276s

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 641640-05-3
(4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenylthio)methyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C

2.1: 85 percent / methanol / 70 °C

3.1: trimethylaluminum / hexane; CH₂Cl₂ / 0 - 20 °C

3.2: 93 percent / hexane; CH₂Cl₂ / 20 °C

4.1: 48 percent / tetrahydrofuran / 0 - 20 °C

5.1: 45 percent / magnesium monoperoxyphthalate hexahydrate / methanol; CH₂Cl₂ / 1 h / 20 °C

6.1: 56 percent / sodium acetate / 8 h / Heating

With trimethylaluminum; sodium methylate; sodium acetate; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; 6.1: Pummerer rearrangement;
DOI:10.1021/jm030276s

Reference yield:

: 346684-15-9
methyl (2Z)-2-hydroxy-4-(4-methylthiophenyl)-4-oxobut-2-enoate

: 641640-05-3
(4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenylthio)methyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / methanol / 70 °C

2.1: trimethylaluminum / hexane; CH₂Cl₂ / 0 - 20 °C

2.2: 93 percent / hexane; CH₂Cl₂ / 20 °C

3.1: 48 percent / tetrahydrofuran / 0 - 20 °C

4.1: 45 percent / magnesium monoperoxyphthalate hexahydrate / methanol; CH₂Cl₂ / 1 h / 20 °C

5.1: 56 percent / sodium acetate / 8 h / Heating

With trimethylaluminum; sodium acetate; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; methanol; hexane; dichloromethane; 5.1: Pummerer rearrangement;
DOI:10.1021/jm030276s