1190865-44-1Relevant articles and documents
METHOD FOR PREPARING 3,5-DIHALOTRIFLUOROACETOPHENONE AND DERIVATIVE THEREOF
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, (2022/04/03)
The present application relates to the technical field of chemical pharmacy, and in particular, to a method for preparing 3,5-dihalotrifluoroacetophenone and a derivative thereof. 3-halogen-4-nitrotrifluoroacetophenone is used as a raw material, and the 3,5-dihalotrifluoroacetophenone derivative is finally obtained by means of a reduction reaction, a halogenation reaction and an amino substitution reaction. The raw material thereof is cheap and easily available, the process is simple, the conditions are mild, and the method has the prospect of large-scale production and has good economic effects.
Synthesis method of 3',5'-dichloro-2,2,2-trifluoroacetophenone derivative
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Paragraph 0028-0033; 0062-0063, (2021/06/26)
The invention relates to the technical field of chemical pharmacy, in particular to a synthesis method of a 3',5'-dichloro-2,2,2-trifluoroacetophenone derivative, which specifically comprises the following steps: S1, preparing a Grignard reagent from a 1-bromo-3,5-dichloro-4-substituted compound through a Grignard reagent; and S2, subjecting a Grignard reagent and a trifluoroacetyl compound to a reaction, and then conducting acid treatment, so as to obtain the 3',5'-dichloro-2,2,2-trifluoroacetophenone derivative. According to the technical scheme, reaction conditions are mild, raw materials are easy to obtain, the yield is high, the production cost of enterprises can be saved, and the 3',5'-dichloro-2,2,2-trifluoroacetophenone derivative is suitable for large-scale production.
Preparation method of halogenated trifluoroacetyl benzene
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, (2021/06/02)
The invention relates to the field of organic synthesis, in particular to a preparation method of halogenated trifluoroacetyl benzene. The invention provides a preparation method of 3,4,5-trichlorotrifluoroacetyl benzene on the first aspect, which comprises the following steps: 1) carrying out diazotization and chlorination reaction on 2,6-dichloro-4-bromoaniline to provide 3,4,5-trichlorobromobenzene; (2) carrying out Grignard reaction on the 3,4,5-trichlorobromobenzene so as to provide 3,4,5-trichlorophenyl magnesium bromide; and 3) carrying out a trifluoroacetylation reaction on the 3,4,5-trichlorophenyl magnesium bromide and a trifluoroacetylation reagent, so as to provide the 3,4,5-trichlorotrifluoroacetyl benzene. According to the preparation method of 3,4,5-trichlorotrifluoroacetyl benzene, provided by the invention, 2,6-dichloro-4-bromoaniline is adopted as a raw material, a target product is prepared through a diazotization reaction, a Grignard reaction and a trifluoroacetylation reaction, the whole preparation route is simple in reaction step operation, the product is easy to purify, the yield is high, and the preparation method is very suitable for large-scale production; and the method has a good industrialization prospect.