N-Hydroxypentafluoro benzamide

Base Information

• Chemical Name: N-Hydroxypentafluoro benzamide
• CAS No.: 80684-62-4
• Molecular Formula: C7H2F5NO2
• Molecular Weight: 227.09
• DSSTox Substance ID: DTXSID80230500
• Nikkaji Number: J2.741.572E
• Wikidata: Q83111075
• Mol file: 80684-62-4.mol

Synonyms:N-Hydroxypentafluoro benzamide;2,3,4,5,6-pentafluoro-N-hydroxybenzamide;80684-62-4;DTXSID80230500;AKOS009084310;QI5

Chemical Property of N-Hydroxypentafluoro benzamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.722g/cm³
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 1
• Exact Mass: 227.00056912
• Heavy Atom Count: 15
• Complexity: 238

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1(=C(C(=C(C(=C1F)F)F)F)F)C(=O)NO

Technology Process of N-Hydroxypentafluoro benzamide

There total 2 articles about N-Hydroxypentafluoro benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-benzyloxy-F-benzamide (80684-61-3) → F-benzohydroxamic acid (80684-62-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1246/bcsj.54.3447

Reference yield: 69.0%

pentafluorobenzoylchloride (2251-50-5) → F-benzohydroxamic acid (80684-62-4)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In 1,4-dioxane; at 20 ℃; for 0.5h;

DOI:10.1016/S0022-1139(00)82068-0

Reference yield: 80.0%

F-benzohydroxamic acid (80684-62-4) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → bis-(trimethylsilyl)-2,3,4,5,6-pentafluorobenzohydroxamic acid

Guidance literature:

at 20 ℃; for 48h;

DOI:10.1016/S0022-1139(00)82068-0

upstream raw materials:

pentafluorobenzoylchloride

N-benzyloxy-F-benzamide

Downstream raw materials:

2,3,4,5,6-pentafluoroaniline

Pentafluorobenzoic acid

1,2-(F-benz)isoxazol-3(2H)-one

pentafluorophenyl isocyanate