IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-

Base Information

• Chemical Name: IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-
• CAS No.: 1126635-20-8
• Molecular Formula: C₁₃H₉FN₂
• Molecular Weight: 212.226
• Mol file: 1126635-20-8.mol

Synonyms:IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-;6-Fluoro-2-phenylimidazo[1,2-a]pyridine

Chemical Property of IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-

Chemical Property:

• PSA: 17.30000
• LogP: 3.14040
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-fluoro-2-phenyl-Imidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-

There total 8 articles about IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-amino-5-fluoropyridine (21717-96-4) + α-bromoacetophenone (70-11-1) → 6-fluoro-2-phenylimidazo[1,2-α]pyridine (1126635-20-8)

Guidance literature:

With sodium hydrogencarbonate; In toluene; for 12h; Reflux;

DOI:10.1016/j.ejmech.2016.08.059

Reference yield: 71.0%

ethylbenzene (100-41-4,27536-89-6) + 2-amino-5-fluoropyridine (21717-96-4) → 6-fluoro-2-phenylimidazo[1,2-α]pyridine (1126635-20-8)

Guidance literature:

ethylbenzene; With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In water; ethyl acetate; at 65 ℃; for 1.5h;

2-amino-5-fluoropyridine; With sodium carbonate; In water; at 80 ℃;

DOI:10.3390/molecules24050893

Reference yield:

2-amino-5-fluoropyridine (21717-96-4) + acetophenone (98-86-2) → 6-fluoro-2-phenylimidazo[1,2-α]pyridine (1126635-20-8)

Guidance literature:

acetophenone; With iodine; copper(II) oxide; In methanol; Reflux;

2-amino-5-fluoropyridine; In methanol; Reflux;

DOI:10.1016/j.tetlet.2019.02.001

upstream raw materials:

2-amino-5-fluoropyridine

α-bromoacetophenone

acetophenone

ethylbenzene