4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

Base Information

Chemical Name:4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde
CAS No.:1228837-05-5
Molecular Formula:C15H17ClO
Molecular Weight:248.752
Hs Code.:
Mol file:1228837-05-5.mol

Synonyms:4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde;2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde;2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carbaldehyde;2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-enecarboxaldehyde;2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enecarbaldehyde

Suppliers and Price of 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde
1g
$ 50.00

Matrix Scientific
4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde 97%
10g
$ 3150.00

Chemenu
4''-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1''-biphenyl]-2-carbaldehyde 95+%
25g
$ 729.00

Chemenu
4''-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1''-biphenyl]-2-carbaldehyde 95+%
10g
$ 365.00

Chemenu
4''-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1''-biphenyl]-2-carbaldehyde 95+%
5g
$ 224.00

Ambeed
4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde 96%
100g
$ 222.00

Alichem
4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde
25g
$ 764.40

Alichem
4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde
10g
$ 401.70

AK Scientific
2-(4-Chlorophenyl)-4,4-dimethylcyclohexene-1-carbaldehyde
1g
$ 298.00

Total 44 raw suppliers

Chemical Property of 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

Chemical Property:

Boiling Point:347.9±42.0 °C(Predicted)
PSA：17.07000
Density:1.147±0.06 g/cm3(Predicted)
LogP:4.50260
Storage Temp.:Refrigerator, under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde is an intermediate in various reactions. For example, its an intermediate in preparation of N-?(phenylsulfonyl)?benzamides and N-?(3-?pyridylsulfonyl)?benzamides as apoptosis-?inducing agents for the treatment of cancer and immune diseases and autoimmune diseases.

Technology Process of 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

There total 6 articles about 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 17151-48-3
tributyl(4-chlorophenyl)stannane

: 251980-67-3
2-bromo-4,4-dimethylcyclohex-1-ene-1-carbaldehyde

: 1228837-05-5
4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

Guidance literature:: With potassium fluoride; copper(l) iodide; tetraethylene glycol monododecyl ether; tetrabutyl-ammonium chloride; C₃₄H₃₄NO₃PPdS; In tetrahydrofuran; water; at 55 ℃; for 10h; Inert atmosphere;
DOI:10.1002/anie.202014141

Reference yield: 93.7%

: 1228943-80-3
2-chloro-4,4-dimethyl-2-oxocyclohexenecarbaldehyde

: 1679-18-1
4-Chlorophenylboronic acid

: 1228837-05-5
4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

Guidance literature:: 2-chloro-4,4-dimethyl-2-oxocyclohexenecarbaldehyde; With tetrabutylammomium bromide; In acetonitrile; at 20 ℃; for 0.166667h;

With potassium carbonate; In acetonitrile; at 20 ℃; for 0.166667h;

4-Chlorophenylboronic acid; In acetonitrile; at 20 - 30 ℃; for 12h; Inert atmosphere;

Reference yield: 53.0%

: 1679-18-1
4-Chlorophenylboronic acid

: 251980-67-3
2-bromo-4,4-dimethylcyclohex-1-ene-1-carbaldehyde

: 1228837-05-5
4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; at 120 ℃; for 3h; Inert atmosphere;