(R)-Methyl 2-(pyrrolidin-2-yl)acetate hydrochloride

Base Information

• Chemical Name: (R)-Methyl 2-(pyrrolidin-2-yl)acetate hydrochloride
• CAS No.: 340040-67-7
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.647
• Hs Code.: 2933990090
• Mol file: 340040-67-7.mol

Synonyms:(R)-Methyl 2-(pyrrolidin-2-yl)acetate hydrochloride;(2R)-2-Pyrrolidineacetic acid methyl ester hydrochloride;(R)-Methyl 2-pyrrolidineacetate HCl

Chemical Property of (R)-Methyl 2-(pyrrolidin-2-yl)acetate hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 1.43230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl(R)-2-PyrrolidineacetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl (R)-2-Pyrrolidineacetate is a useful reagent for preparing enantiomeric 2-pyrrolidineacetic acids.

Technology Process of (R)-Methyl 2-(pyrrolidin-2-yl)acetate hydrochloride

There total 2 articles about (R)-Methyl 2-(pyrrolidin-2-yl)acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (R)-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanoate (132482-05-4,813433-68-0) → methyl 2-[(2R)-pyrrolidin-2-yl]acetate hydrochloride (340040-67-7,259868-83-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

Reference yield:

methanol (67-56-1) + 2-[(2R)-1-methylpyrrolidin-2-yl]acetic acid (1174705-02-2) → methyl 2-[(2R)-pyrrolidin-2-yl]acetate hydrochloride (340040-67-7,259868-83-2)

Guidance literature:

With thionyl chloride; at 0 ℃;

Reference yield:

methyl 2-[(2R)-pyrrolidin-2-yl]acetate hydrochloride (340040-67-7,259868-83-2) + 5-iodo-2-(2-methoxy-ethoxymethoxy)-benzyl bromide (205055-04-5) → 3-[5-Iodo-2-(2-methoxyethoxymethoxy)phenyl]-2-pyrrolidin-2-yl propionic acid methyl ester

Guidance literature:

upstream raw materials:

methyl (R)-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanoate

methanol

2-[(2R)-1-methylpyrrolidin-2-yl]acetic acid