3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-amine

Base Information

• Chemical Name: 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-amine
• CAS No.: 945994-98-9
• Molecular Formula: C₁₉H₃₀ClN₃OSi
• Molecular Weight: 380.005

Synonyms:3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-amine

Chemical Property of 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-amine

There total 5 articles about 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)-2-chlorophenol (945994-86-5) + tert-butyldimethylsilyl chloride (18162-48-6) → 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-amine (945994-98-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

3-chloro-4-hydroxyphenylhydrazine hydrochloride (243141-12-0) → 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-amine (945994-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / Reflux

1.2: 2 h

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 1H-imidazole; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm200677b

Reference yield:

trimethylacetylacetonitrile (59997-51-2) → 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-amine (945994-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / Reflux

1.2: 2 h

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 1H-imidazole; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm200677b

upstream raw materials:

4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)-2-chlorophenol

tert-butyldimethylsilyl chloride

3-chloro-4-hydroxyphenylhydrazine hydrochloride

trimethylacetylacetonitrile

Downstream raw materials:

phenyl [3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-yl]carbamate

1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(2-hydroxyethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2-[(3-{2-[(2-hydroxyethyl)sulfinyl]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}urea

(1-[5-tert-butyl-2-(3-chloro-4-hydroxyphenyl)pyrazol-3-yl]-3-[[2-[[3-[2-(2-hydroxyethylsulfanyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl]phenyl]methyl]urea)

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