3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester

Base Information

Chemical Name:3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester
CAS No.:52759-80-5
Molecular Formula:C31H58O4Si2
Molecular Weight:550.97
Hs Code.:
Mol file:52759-80-5.mol

Synonyms:3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester

Suppliers and Price of 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester

Chemical Property:

PSA：44.76000
LogP:8.28470

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester

There total 8 articles about 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 3057-04-3
chenodeoxycholic acid methyl ester

: 52759-80-5
methyl 3α-7α-ditrimethylsilyloxy-5β-chol-6-en-24-oate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; for 0.25h;
DOI:10.1016/S0039-128X(98)00066-X

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 10538-59-7
7-ketolithocholic methyl ester

: 52759-80-5
methyl 3α-7α-ditrimethylsilyloxy-5β-chol-6-en-24-oate

Guidance literature:: 7-ketolithocholic methyl ester; With sodium hydrogencarbonate; In water; toluene; at 25 - 110 ℃; for 2h;

With sodium iodide; In toluene; acetonitrile; at 25 - 95 ℃; for 2h; Inert atmosphere;

chloro-trimethyl-silane; Temperature; Reagent/catalyst; Further stages;

Reference yield:

: 474-25-9
chenodeoxycholic acid

: 52759-80-5
methyl 3α-7α-ditrimethylsilyloxy-5β-chol-6-en-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1: TMSCl / 0.33 h / Heating

2: LDA / tetrahydrofuran / 0.25 h / -78 - 0 °C

With chloro-trimethyl-silane; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0039-128X(98)00066-X