(3R)-1-BENZYL-3-CHLOROPIPERIDINE

Base Information

Chemical Name:(3R)-1-BENZYL-3-CHLOROPIPERIDINE
CAS No.:240132-25-6
Molecular Formula:C12H16ClN
Molecular Weight:209.719
Hs Code.:2933399090
Mol file:240132-25-6.mol

Synonyms:(3R)-1-BENZYL-3-CHLOROPIPERIDINE

Suppliers and Price of (3R)-1-BENZYL-3-CHLOROPIPERIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-1-Benzyl-3-chloro-piperidine 95+%
1g
$ 1105.00

Total 6 raw suppliers

Chemical Property of (3R)-1-BENZYL-3-CHLOROPIPERIDINE

Chemical Property:

PSA：3.24000
LogP:2.82770

Purity/Quality:

98%min ^*data from raw suppliers

(R)-1-Benzyl-3-chloro-piperidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3R)-1-BENZYL-3-CHLOROPIPERIDINE

There total 4 articles about (3R)-1-BENZYL-3-CHLOROPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 53912-80-4
(S)-N-benzylprolinol

: 240132-25-6,1354017-94-9
(-)-(3R)-1-benzyl-3-chloropiperidine

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1021/jo900031e

Reference yield:

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 240132-25-6,1354017-94-9
(-)-(3R)-1-benzyl-3-chloropiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 21 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 20 h / 0 - 20 °C

With methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.202101072

Reference yield:

: 100-39-0
benzyl bromide

: 240132-25-6,1354017-94-9
(-)-(3R)-1-benzyl-3-chloropiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 21 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 20 h / 0 - 20 °C

With methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.202101072