ETHYL 2-(DIETHOXYPHOSPORYL)-2-HYDROXYACETATE

Base Information

• Chemical Name: ETHYL 2-(DIETHOXYPHOSPORYL)-2-HYDROXYACETATE
• CAS No.: 162246-79-9
• Molecular Formula: C8H17O6P
• Molecular Weight: 240.19
• Mol file: 162246-79-9.mol

Synonyms:ETHYL 2-(DIETHOXYPHOSPORYL)-2-HYDROXYACETATE;(Diethoxyphosphinyl)hydroxy-acetic Acid Ethyl Ester;2-(Diethoxyphosphinyl)-2-hydroxy-acetic Acid Ethyl Ester

Chemical Property of ETHYL 2-(DIETHOXYPHOSPORYL)-2-HYDROXYACETATE

Chemical Property:

• Boiling Point: 125-142°C/Oil Pump
• PKA: 10.97±0.20(Predicted)
• PSA: 91.87000
• Density: 1.208±0.06 g/cm3(Predicted)
• LogP: 1.13400
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)l

Purity/Quality:

95% ^*data from raw suppliers

Ethyl2-(Diethoxyphosporyl)-2-hydroxyacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ethyl 2-(Diethoxyphosporyl)-2-Hydroxyacetate is a useful wittig reagent.

Technology Process of ETHYL 2-(DIETHOXYPHOSPORYL)-2-HYDROXYACETATE

There total 2 articles about ETHYL 2-(DIETHOXYPHOSPORYL)-2-HYDROXYACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 2-ethoxyglycolate (49653-17-0) + phosphonic acid diethyl ester (762-04-9) → ethyl 2-(diethoxyphosphoryl)-2-hydroxyacetate (162246-79-9)

Guidance literature:

at 80 ℃; for 5h;

DOI:10.1055/s-1994-25656

Reference yield: 64.0%

glyoxylic acid ethyl ester (924-44-7) + phosphonic acid diethyl ester (762-04-9) → ethyl 2-(diethoxyphosphoryl)-2-hydroxyacetate (162246-79-9)

Guidance literature:

With toluene-4-sulfonic acid; In water; toluene; for 12h; Reflux;

Reference yield: 72.0%

acetyl chloride (75-36-5) + ethyl 2-(diethoxyphosphoryl)-2-hydroxyacetate (162246-79-9) → acetoxy(diethoxyphosphoryl)acetic acid ethyl ester (162246-77-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃;

DOI:10.1055/s-1994-25656

upstream raw materials:

ethyl 2-ethoxyglycolate

phosphonic acid diethyl ester

glyoxylic acid ethyl ester

Downstream raw materials:

acetoxy(diethoxyphosphoryl)acetic acid ethyl ester

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