Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate

Base Information

• Chemical Name: Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate
• CAS No.: 162246-77-7
• Molecular Formula: C10H19 O7 P
• Molecular Weight: 282.23
• European Community (EC) Number: 837-335-4
• DSSTox Substance ID: DTXSID70399675
• Nikkaji Number: J2.310.199H
• Mol file: 162246-77-7.mol

Synonyms:162246-77-7;ETHYL 2-ACETOXY-2-(DIETHOXYPHOSPHORYL)ACETATE;ethyl 2-acetyloxy-2-diethoxyphosphorylacetate;ethyl (acetyloxy)(diethoxyphosphoryl)acetate;Acetic acid, 2-(acetyloxy)-2-(diethoxyphosphinyl)-, ethyl ester;SCHEMBL584805;Acetic acid, (acetyloxy)(diethoxyphosphinyl)-, ethyl ester;DTXSID70399675;QHQNXSICNKWLOC-UHFFFAOYSA-N;AR3110;MFCD04039534;AKOS016344388;ethyl acetoxy(diethoxyphosphoryl)acetate;ethyl (acetoxy)(diethoxyphosphoryl)acetate;BB 0260847;CS-0139650;FT-0668135;EN300-234955;A924912;Acetoxy(diethoxyphosphinyl)acetic acid ethyl ester;Acetoxy(diethoxyphosphorvl)acetic Acid Ethyl Ester;Acetoxy(diethoxyphosphoryl)acetic Acid Ethyl Ester;ethyl 2-(acetyloxy)-2-(diethyl phosphono)acetate;ETHYL 2-ACETOXY-2-(DIETHOXYPHOSPORYL)ACETATE;ETHYL2-ACETOXY-2-(DIETHOXYPHOSPHORYL)ACETATE;J-009909;F2184-0214

Chemical Property of Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate

Chemical Property:

• Vapor Pressure: 2.08E-05mmHg at 25°C
• Refractive Index: 1.436
• Boiling Point: 100°C/10-3 Torr
• Flash Point: 186°C
• PSA: 97.94000
• Density: 1.186g/cm³
• LogP: 1.70480
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Ethyl Acetate
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 282.08683994
• Heavy Atom Count: 18
• Complexity: 318

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-Acetoxy-2-(diethoxyphosphoryl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(OC(=O)C)P(=O)(OCC)OCC
• Uses: A useful wittig reagent. ETHYL 2-ACETOXY-2-(DIETHOXYPHOSPHORYL)ACETATE is a useful wittig reagent

Technology Process of Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate

There total 4 articles about Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

acetyl chloride (75-36-5) + ethyl 2-(diethoxyphosphoryl)-2-hydroxyacetate (162246-79-9) → acetoxy(diethoxyphosphoryl)acetic acid ethyl ester (162246-77-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃;

DOI:10.1055/s-1994-25656

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + acetic anhydride (108-24-7) + phosphonic acid diethyl ester (762-04-9) → acetoxy(diethoxyphosphoryl)acetic acid ethyl ester (162246-77-7)

Guidance literature:

glyoxylic acid ethyl ester; phosphonic acid diethyl ester; With triethylamine; In toluene; at 0 - 20 ℃; Inert atmosphere;

acetic anhydride; In toluene; at 0 - 20 ℃;

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + Diethyl phosphonate (762-04-9,123-22-8) + acetic anhydride (108-24-7) → acetoxy(diethoxyphosphoryl)acetic acid ethyl ester (162246-77-7)

Guidance literature:

glyoxylic acid ethyl ester; Diethyl phosphonate; With triethylamine; In toluene; at 0 - 20 ℃; Inert atmosphere;

acetic anhydride; In toluene; at 0 - 20 ℃;

upstream raw materials:

acetyl chloride

ethyl 2-(diethoxyphosphoryl)-2-hydroxyacetate

acetic anhydride

glyoxylic acid ethyl ester

Downstream raw materials:

ethyl (S)-2-acetoxy-3-phenylpropanoate

α-acetoxy-cinnamic acid ethyl ester