2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide

Base Information

Chemical Name:2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide
CAS No.:308336-42-7
Molecular Formula:C10H9F3INO
Molecular Weight:343.087
Hs Code.:
DSSTox Substance ID:DTXSID20573221
Wikidata:Q82461848
Mol file:308336-42-7.mol

Synonyms:2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide;308336-42-7;SCHEMBL4702861;DTXSID20573221;SUEYNLYWEZTDHC-UHFFFAOYSA-N

Suppliers and Price of 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide

Chemical Property:

PSA：32.59000
LogP:3.35250
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:342.96810
Heavy Atom Count:16
Complexity:237

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CCNC(=O)C(F)(F)F)I

Technology Process of 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide

There total 4 articles about 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 458-85-5
2,2,2-trifluoro-N-(2-phenylethyl)acetamide

: 2,2,2-trifluoro-N-(2-(2-iodophenyl)ethyl)acetamide

: 308336-42-7
2,2,2-Trifluoro-N-(2-(4-iodophenyl)ethyl)acetamide

Guidance literature:: With tetrafluoroboric acid; trifluoroacetic acid; In diethyl ether; dichloromethane; at 20 ℃; for 2h;
DOI:10.1002/anie.200603631

Reference yield: 52.1%

: 458-85-5
2,2,2-trifluoro-N-(2-phenylethyl)acetamide

: 7553-56-2,12190-71-5,8031-47-8
iodine

: 308336-42-7
2,2,2-Trifluoro-N-(2-(4-iodophenyl)ethyl)acetamide

Guidance literature:: 2,2,2-trifluoro-N-(2-phenylethyl)acetamide; iodine; With sulfuric acid; periodic acid; In water; acetic acid; at 55 - 70 ℃; for 2h;

In water; acetic acid; at 70 ℃; for 2h;

iodine; In water; acetic acid; at 70 ℃; for 0.5h;

Reference yield:

: 64-04-0
phenethylamine

: 308336-42-7
2,2,2-Trifluoro-N-(2-(4-iodophenyl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / -5 °C

1.2: 0.17 h / 22 °C

1.3: 0.5 h / 20 °C

2.1: sulfuric acid; periodic acid / water; acetic acid / 2 h / 55 - 70 °C

2.2: 2 h / 70 °C

2.3: 0.5 h / 70 °C

With sulfuric acid; periodic acid; triethylamine; In dichloromethane; water; acetic acid;