tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester

Base Information

Chemical Name:tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester
CAS No.:360792-42-3
Molecular Formula:C₂₁H₂₉BF₃NO₅
Molecular Weight:443.271
Hs Code.:

Synonyms:tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester

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Chemical Property of tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester

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Technology Process of tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester

There total 6 articles about tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

: 344463-04-3
2,2,2-Trifluoro-N-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-acetamide

: 24424-99-5
di-tert-butyl dicarbonate

: 360792-42-3
tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;

Reference yield:

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 360792-42-3
tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-dimethyl sulfide complex / dichloromethane / 4 h / 0 °C

1.2: 20 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 3.5 h / 70 °C

3.1: dmap / dichloromethane / 20 °C

With dmap; borane-dimethyl sulfide complex; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; acetonitrile;

Reference yield:

: 64-04-0
phenethylamine

: 360792-42-3
tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / -5 °C

1.2: 0.17 h / 22 °C

1.3: 0.5 h / 20 °C

2.1: sulfuric acid; periodic acid / water; acetic acid / 2 h / 55 - 70 °C

2.2: 2 h / 70 °C

2.3: 0.5 h / 70 °C

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 3.5 h / 70 °C

4.1: dmap / dichloromethane / 20 °C

With dmap; sulfuric acid; periodic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; water; acetic acid; acetonitrile;