5-Fluoro-N-Methoxy-N-MethylnicotinaMide

Base Information

• Chemical Name: 5-Fluoro-N-Methoxy-N-MethylnicotinaMide
• CAS No.: 342602-54-4
• Molecular Formula: C₈H₉FN₂O₂
• Molecular Weight: 184.17
• Hs Code.: 2933399990
• Mol file: 342602-54-4.mol

Synonyms:5-Fluoro-N-Methoxy-N-MethylnicotinaMide;5-fluoro-N-methoxy-N-methyl-3-Pyridinecarboxamide

Chemical Property of 5-Fluoro-N-Methoxy-N-MethylnicotinaMide

Chemical Property:

• PSA: 42.43000
• LogP: 0.85410

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-N-methoxy-N-methylnicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-N-Methoxy-N-MethylnicotinaMide

There total 1 articles about 5-Fluoro-N-Methoxy-N-MethylnicotinaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

5-fluoropyridine-3-carboxylic acid (402-66-4) + N,0-dimethylhydroxylamine (1117-97-1) → 5-fluoro-N-methoxy-N-methylnicotinamide (342602-54-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield: 74.0%

5-fluoro-N-methoxy-N-methylnicotinamide (342602-54-4) + methylmagnesium bromide (75-16-1) → 1-(5-fluoropyridin-3-yl)ethan-1-one (342602-55-5)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 ℃; for 4h; Inert atmosphere;

Reference yield:

5-fluoro-N-methoxy-N-methylnicotinamide (342602-54-4) → 1-(5-fluoro-6-(1-methylcyclopropyl)pyridin-3-yl)ethan-1-one

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / 4 h / 0 °C / Inert atmosphere

2: silver nitrate; sulfuric acid; ammonium persulfate / water / 3 h / 20 °C

With ammonium persulfate; sulfuric acid; silver nitrate; In tetrahydrofuran; diethyl ether; water;

upstream raw materials:

5-fluoropyridine-3-carboxylic acid

N,0-dimethylhydroxylamine

Downstream raw materials:

1-(5-fluoropyridin-3-yl)ethan-1-one

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