5-BroMo-1,3-diMethyl-1H-indole

Base Information

• Chemical Name: 5-BroMo-1,3-diMethyl-1H-indole
• CAS No.: 10075-49-7
• Molecular Formula: C10H10BrN
• Molecular Weight: 224.1
• Mol file: 10075-49-7.mol

Synonyms:5-BroMo-1,3-diMethyl-1H-indole

Chemical Property of 5-BroMo-1,3-diMethyl-1H-indole

Chemical Property:

• PSA: 4.93000
• LogP: 3.24920
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-1,3-dimethyl-1H-indole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-1,3-diMethyl-1H-indole

There total 8 articles about 5-BroMo-1,3-diMethyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-bromo-3-methyl-1H-indole (10075-48-6) + methyl iodide (74-88-4) → N-methyl-3-methyl-5-bromoindole (10075-49-7)

Guidance literature:

5-bromo-3-methyl-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

Reference yield: 93.2%

5-bromo-3-methyl-1H-indole (10075-48-6) + ethyl iodide (75-03-6) → N-methyl-3-methyl-5-bromoindole (10075-49-7)

Guidance literature:

5-bromo-3-methyl-1H-indole; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 5 ℃; for 1.1h;

ethyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

Reference yield:

C9H11BrN2 → N-methyl-3-methyl-5-bromoindole (10075-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc(II) chloride / para-xylene / 160 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydride; zinc(II) chloride; In para-xylene; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ol501094z

upstream raw materials:

5-bromo-3-methyl-1H-indole

methyl iodide

(4-bromophenyl)hydrazine

5-bromo-1H-indole-3-carboxaldehyde

Downstream raw materials:

C₁₉H₁₉BrN₂O₂S

Refernces

• 1、 DiPoto, Maria C.,Hughes, Russell P.,Wu, Jimmy. "Dearomative Indole (3 + 2) Reactions with Azaoxyallyl Cations - New Method for the Synthesis of Pyrroloindolines". . p. 14861 - 14864. Retrieved 2015.
• 2、 An, Yuehui,Chen, Yidian,Duan, Shengguo,Li, Chuan-Ying,Xu, Ze-Feng,Xue, Bing,Zhang, Wan. "Synthesis of Pyrido[2,3-b]indole Derivatives via Rhodium-Catalyzed Cyclization of Indoles and 1-Sulfonyl-1,2,3-triazoles". supporting information. . Retrieved 2020/04/22.
• 3、 -. "PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS". Page/Page column 122. . Retrieved 2018/12/13.