1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanone

Base Information

• Chemical Name: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanone
• CAS No.: 122243-34-9
• Molecular Formula: C10H7F3O3
• Molecular Weight: 232.159
• Hs Code.: 2932999099
• Mol file: 122243-34-9.mol

Synonyms:1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanone

Chemical Property of 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanone

Chemical Property:

• PSA: 35.53000
• LogP: 2.20280
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-2,2,2-TRIFLUOROETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanone

There total 2 articles about 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanol (923170-94-9) → 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethan-1-one (122243-34-9)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 11h; Reagent/catalyst; Reflux;

DOI:10.1016/j.tetlet.2013.06.045

Reference yield:

2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde (29668-44-8) → 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethan-1-one (122243-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

1.2: 4 h / Acidic conditions

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 11 h / Reflux

With potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2013.06.045

Reference yield: 4.5%

4-cyclohexyl-2-butanone (2316-85-0) + 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethan-1-one (122243-34-9) → C20H25F3O4

Guidance literature:

4-cyclohexyl-2-butanone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.75h;

1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethan-1-one; In tetrahydrofuran; at -78 ℃; for 4h;

DOI:10.1016/j.ejmech.2019.111906

upstream raw materials:

1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanol

2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde

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