953039-66-2

Basic information

• Product Name: 7-bromo-2-chloroquinazoline
• Synonyms: 7-bromo-2-chloroquinazoline;7-BroMo-2-chloroquinazoli...;Quinazoline, 7-broMo-2-chloro-
• CAS NO: 953039-66-2
• Molecular Formula: C₈H₄BrClN₂
• Molecular Weight: 243.5
• Product Categories: CHIRAL CHEMICALS;intermediate
• Mol File: 953039-66-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 240.2 °C at 760 mmHg
• Flash Point: 99.1 °C
• Appearance: /
• Density: 1.762±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0596mmHg at 25°C
• Refractive Index: 1.691
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.51±0.30(Predicted)
• CAS DataBase Reference: 7-bromo-2-chloroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-2-chloroquinazoline(953039-66-2)
• EPA Substance Registry System: 7-bromo-2-chloroquinazoline(953039-66-2)

Safety Data

• Hazardous Substances Data: 953039-66-2(Hazardous Substances Data)

Usage

General Description

7-Bromo-2-chloroquinazoline is a chemical compound with the molecular formula C8H5BrClN2. It is a chloro-substituted quinazoline derivative with a bromine atom attached to the seventh position of the quinazoline ring. 7-Bromo-2-chloroquinazoline has been studied for its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and agrochemicals. It is known to exhibit biological activity and has been investigated as a potential candidate for the treatment of various diseases. Additionally, it has been used in chemical synthesis and as a building block in the preparation of other organic compounds. Overall, 7-Bromo-2-chloroquinazoline is a versatile chemical with potential applications in various fields including medicine and industrial chemistry.

InChI:InChI=1/C8H4BrClN2/c9-6-2-1-5-4-11-8(10)12-7(5)3-6/h1-4H

Upstream product

• 22996-19-6 (4-bromo-2-nitrophenyl)methanol 
• 99277-71-1 4-bromo-2-nitrobenzoic acid 
• 59278-65-8 2-amino-4-bromobenzaldehyde 
• 5551-12-2 4-bromo-2-nitrobenzaldehyde 
• 953039-65-1 7-bromo-quinazolin-2-ol 

Downstream Products

• 953039-15-1 2-chloro-7-methoxyquinazoline 
• 1292267-36-7 C₂₅H₁₉N₉ 
• 1292267-70-9 C₂₂H₁₆BrN₇ 
• 1292267-35-6 C₂₆H₂₃N₇O 
• 1292267-34-5 C₂₆H₂₄N₈O 
• 1292267-33-4 C₂₅H₂₂N₈O 
• 1292267-32-3 C₂₄H₂₆N₈O₂ 
• 1292267-27-6 C₂₃H₂₀N₈O₂ 
• 1292267-23-2 C₂₃H₂₁N₉O 
• 1292267-69-6 C₂₀H₁₈BrN₇O 

Relevant articles and documents

NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

QUINAZOLINES FOR PDK1 INHIBITION

The invention provides novel quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.