Methyl 2-bromo-3-methoxybenzoate

Base Information

Chemical Name:Methyl 2-bromo-3-methoxybenzoate
CAS No.:59453-47-3
Molecular Formula:C9H9BrO3
Molecular Weight:245.073
Hs Code.:2918999090
European Community (EC) Number:816-278-9

Synonyms:methyl 2-bromo-3-methoxybenzoate;59453-47-3;2-BROMO-3-METHOXYBENZOIC ACID METHYL ESTER;SCHEMBL2430627;methyl2-bromo-3-methoxybenzoate;JRMOOUWDJRMZGS-UHFFFAOYSA-N;MFCD14697991;PS-11493;CS-0380011;FT-0729517

Suppliers and Price of Methyl 2-bromo-3-methoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Methyl 2-bromo-3-methoxybenzoate
250 mg
$ 192.00

SynQuest Laboratories
Methyl 2-bromo-3-methoxybenzoate
1 g
$ 576.00

Chemcia Scientific
2-Bromo-3-methoxy-benzoicacidmethylester 95%
2.5 G
$ 795.00

Alichem
Methyl2-bromo-3-methoxybenzoate
500mg
$ 790.55

Alichem
Methyl2-bromo-3-methoxybenzoate
250mg
$ 480.00

AHH
2-BROMO-3-METHOXYBENZOICACIDMETHYLESTER 97%
1g
$ 950.00

Total 6 raw suppliers

Chemical Property of Methyl 2-bromo-3-methoxybenzoate

Chemical Property:

PSA：35.53000
LogP:2.24430
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:243.97351
Heavy Atom Count:13
Complexity:184

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-bromo-3-methoxybenzoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC(=C1Br)C(=O)OC

Technology Process of Methyl 2-bromo-3-methoxybenzoate

There total 4 articles about Methyl 2-bromo-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 67-56-1
methanol

: 88377-29-1
2-bromo-3-methoxybenzoic acid

: 59453-47-3
methyl 2-bromo-3-methoxybenzoate

Guidance literature:: With sulfuric acid; for 20h; Heating / reflux;

Reference yield: 50.0%

: 5121-34-6
methyl 2-amino-3-methoxybenzoate

: 59453-47-3
methyl 2-bromo-3-methoxybenzoate

Guidance literature:: methyl 2-amino-3-methoxybenzoate; With hydrogen bromide; In 1,4-dioxane; water; at 20 ℃; for 0.5h;

With sodium nitrite; In 1,4-dioxane; water; at -5 ℃; for 0.5h;

With hydrogen bromide; copper(I) bromide; In 1,4-dioxane; water; at 110 ℃; for 5h;
DOI:10.1021/acs.jmedchem.8b01483

Reference yield:

: 3177-80-8
2-amino-3-methoxybenzoic acid

: 59453-47-3
methyl 2-bromo-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 80 °C / Cooling with ice; Inert atmosphere

2.1: hydrogen bromide / water; 1,4-dioxane / 0.5 h / 20 °C

2.2: 0.5 h / -5 °C

2.3: 5 h / 110 °C

With thionyl chloride; hydrogen bromide; In 1,4-dioxane; water;
DOI:10.1021/acs.jmedchem.8b01483