(R)-2-AMINO-3-(3,4-DIMETHOXYPHENYL)PROPAN-1-OL

Base Information

• Chemical Name: (R)-2-AMINO-3-(3,4-DIMETHOXYPHENYL)PROPAN-1-OL
• CAS No.: 163957-35-5
• Molecular Formula: C₁₁H₁₇NO₃
• Molecular Weight: 211.261
• Mol file: 163957-35-5.mol

Synonyms:(R)-2-AMINO-3-(3,4-DIMETHOXYPHENYL)PROPAN-1-OL;REF DUPL: (R)-beta-(3,4-dimethoxyphenyl)alaninol

Chemical Property of (R)-2-AMINO-3-(3,4-DIMETHOXYPHENYL)PROPAN-1-OL

Chemical Property:

• Boiling Point: 382.0±37.0 °C(Predicted)
• PKA: 12.69±0.10(Predicted)
• PSA: 64.71000
• Density: 1.121±0.06 g/cm3(Predicted)
• LogP: 1.26620

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-AMINO-3-(3,4-DIMETHOXYPHENYL)PROPAN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-AMINO-3-(3,4-DIMETHOXYPHENYL)PROPAN-1-OL

There total 1 articles about (R)-2-AMINO-3-(3,4-DIMETHOXYPHENYL)PROPAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + (R)-2-amino-3-(3,4-dimethoxyphenyl)propanoic acid (33605-56-0) → (2R)-2-amino-3-(3,4-dimethoxyphenyl)propan-1-ol (163957-35-5)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2004.05.060

Reference yield: 71.0%

3-(2-oxocyclopentyl)propionic acid (3296-45-5) + (2R)-2-amino-3-(3,4-dimethoxyphenyl)propan-1-ol (163957-35-5) → (3R,6aR,9aS)-3-(3,4-dimethoxybenzyl)-octahydro-1-oxa-3a-azacyclopenta[d]inden-4-one (1042308-60-0)

Guidance literature:

In toluene; for 48h; Heating;

DOI:10.1021/jo801019h

upstream raw materials:

chloro-trimethyl-silane

(R)-2-amino-3-(3,4-dimethoxyphenyl)propanoic acid

Downstream raw materials:

(3R,6aR,9aS)-3-(3,4-dimethoxybenzyl)-octahydro-1-oxa-3a-azacyclopenta[d]inden-4-one