Z-9-aMino-4,7-dioxanonanoic acid

Base Information

• Chemical Name: Z-9-aMino-4,7-dioxanonanoic acid
• CAS No.: 462100-05-6
• Molecular Formula: C₁₆H₂₃NO₇
• Molecular Weight: 341.361
• Mol file: 462100-05-6.mol

Synonyms:Z-9-aMino-4,7-dioxanonanoic acid;Z-NH-PEG2-CH2CH2COOH;Z-NH-PEG3-CH2COOH;Cbz-NH-PEG2-CH2CH2COOH;CBZ-9-aMino-4,7-dioxanonanoic acid;CBZ-AEEEA;CBZ-NH-PEG3-COOH;5,8,11-Trioxa-2-azatridecanedioic acid 1-(phenylmethyl) ester

Chemical Property of Z-9-aMino-4,7-dioxanonanoic acid

Chemical Property:

• Boiling Point: 534.1±50.0 °C(Predicted)
• PKA: 3.39±0.10(Predicted)
• PSA: 106.81000
• Density: 1.217±0.06 g/cm3(Predicted)
• LogP: 1.25160
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

CBZ-9-amino-4,7-dioxanonanoicacid;CBZ-AEEEA min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-9-aMino-4,7-dioxanonanoic acid

There total 6 articles about Z-9-aMino-4,7-dioxanonanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl N-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]carbamate (206265-31-8) → 2-[2-{2-(N-benzyloxycarbonyl)aminoethoxy}ethoxy]ethoxyacetic acid (462100-05-6)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In water; acetonitrile; at 20 ℃; for 18h;

DOI:10.1021/acsmedchemlett.1c00368

Reference yield: 78.0%

tert-butyl 2-[2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethoxy]acetate (462100-03-4) → 2-[2-{2-(N-benzyloxycarbonyl)aminoethoxy}ethoxy]ethoxyacetic acid (462100-05-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1080/00304940209356773

Reference yield:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) → 2-[2-{2-(N-benzyloxycarbonyl)aminoethoxy}ethoxy]ethoxyacetic acid (462100-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: t-BuOK / tetrahydrofuran / 0.5 h / 0 °C

1.2: 45 percent / tetrahydrofuran / 18 h / 0 - 20 °C

2.1: 78 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 - 20 °C

With potassium tert-butylate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1080/00304940209356773

upstream raw materials:

tert-butyl 2-[2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethoxy]acetate

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

2-[2-{2-(N-benzyloxycarbonyl)aminoethoxy}ethoxy]ethanol

benzyl N-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]carbamate