2,6-Diazaspiro[3.3]heptan-1-one, 2-phenyl-

Base Information

• Chemical Name: 2,6-Diazaspiro[3.3]heptan-1-one, 2-phenyl-
• CAS No.: 960079-47-4
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.229
• Hs Code.: 2933990090
• Mol file: 960079-47-4.mol

Synonyms:2,6-Diazaspiro[3.3]heptan-1-one, 2-phenyl-;2,6-Diazaspiro[3.3]heptan...;2-Phenyl-2,6-diazaspiro[3.3]heptan-1-one;2-Phenyl-2,6-diazaspiro[3.3]heptan-1-one trifluoroacetic acid

Chemical Property of 2,6-Diazaspiro[3.3]heptan-1-one, 2-phenyl-

Chemical Property:

• Vapor Pressure: 1.75E-07mmHg at 25°C
• Boiling Point: 426.6°C at 760 mmHg
• Flash Point: 211.8°C
• PSA: 32.34000
• Density: 1.28g/cm³
• LogP: 1.01660
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2-phenyl-2,6-diazaspiro[3.3]heptan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Diazaspiro[3.3]heptan-1-one, 2-phenyl-

There total 9 articles about 2,6-Diazaspiro[3.3]heptan-1-one, 2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-3,3-bis(chloromethyl)azetidin-2-one (137266-59-2) → 2-phenyl-2,6-diazaspiro[3.3]heptan-1-one (960079-47-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Na / 14 h / 20 °C

1.2: 60 g / K₂CO₃ / toluene / 16 h / Heating

2.1: lithium hydroxide / aq. ethanol

3.1: oxalyl chloride / CH₂Cl₂

4.1: triethylamine / CH₂Cl₂

5.1: 97 percent / sodium hydride / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

6.1: HCO₂NH₄ / Pd(OH)2 / ethanol / 4 h / Heating

With lithium hydroxide; oxalyl dichloride; ammonium formate; sodium; sodium hydride; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-2007-986649

Reference yield:

N-benzyl-3-chloro-2,2-bis(chloromethyl)propanamide (137606-01-0) → 2-phenyl-2,6-diazaspiro[3.3]heptan-1-one (960079-47-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: aq. NaOH / CH₂Cl₂ / 20 °C

2.1: Na / 14 h / 20 °C

2.2: 60 g / K₂CO₃ / toluene / 16 h / Heating

3.1: lithium hydroxide / aq. ethanol

4.1: oxalyl chloride / CH₂Cl₂

5.1: triethylamine / CH₂Cl₂

6.1: 97 percent / sodium hydride / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

7.1: HCO₂NH₄ / Pd(OH)2 / ethanol / 4 h / Heating

With lithium hydroxide; sodium hydroxide; oxalyl dichloride; ammonium formate; sodium; sodium hydride; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-2007-986649

Reference yield:

1-benzyl-3-chloromethylazetidine-3-carboxylic acid ethyl ester (137266-85-4) → 2-phenyl-2,6-diazaspiro[3.3]heptan-1-one (960079-47-4)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium hydroxide / aq. ethanol

2: oxalyl chloride / CH₂Cl₂

3: triethylamine / CH₂Cl₂

4: 97 percent / sodium hydride / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

5: HCO₂NH₄ / Pd(OH)2 / ethanol / 4 h / Heating

With lithium hydroxide; oxalyl dichloride; ammonium formate; sodium hydride; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-2007-986649

upstream raw materials:

6-benzyl-2-phenyl-2,6-diazaspiro[3.3]heptan-1-one

1-benzyl-3-(chloromethyl)azetidine-3-carboxylic acid

3-chloro-2,2-bis(chloromethyl)propionic acid-1

3-chloro-2,2-dipropionyl chloride

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