137266-85-4

Basic information

• Product Name: 1-benzyl-3-chloromethylazetidine-3-carboxylic acid ethyl ester
• Synonyms: 1-benzyl-3-chloromethylazetidine-3-carboxylic acid ethyl ester
• CAS NO: 137266-85-4
• Molecular Weight: 267.755
• Mol File: 137266-85-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-chloromethylazetidine-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-chloromethylazetidine-3-carboxylic acid ethyl ester(137266-85-4)
• EPA Substance Registry System: 1-benzyl-3-chloromethylazetidine-3-carboxylic acid ethyl ester(137266-85-4)

Safety Data

• Hazardous Substances Data: 137266-85-4(Hazardous Substances Data)

Usage

Chemical class

Azetidine carboxylic acid derivatives

Structure

Complex organic molecule with a benzyl group, a chloromethyl group, and an ethyl ester group attached to an azetidine ring

Potential applications

Pharmaceutical research and drug development

Biological activity

Unique structure and potential biological activity

Research status

Properties and potential uses are still being studied and explored by researchers in the chemical and pharmaceutical industries

Upstream product

• 141-52-6 sodium ethanolate 
• 137266-59-2 1-benzyl-3,3-bis(chloromethyl)azetidin-2-one 
• 813-99-0 3-chloro-(2,2-chloromethyl)propan-1-ol 
• 115-77-5 Pentaerythritol 
• 137606-01-0 N-benzyl-3-chloro-2,2-bis(chloromethyl)propanamide 
• 50547-79-0 3-chloro-2,2-dipropionyl chloride 
• 17831-70-8 3-chloro-2,2-bis(chloromethyl)propionic acid-1 
• 64-17-5 ethanol 

Downstream Products

• 960079-48-5 1-benzyl-3-(chloromethyl)azetidine-3-carboxylic acid 
• 106014-95-3 N-benzyl-3-hydroxymethyl-azetidine-3-carboxylic acid 
• 960079-40-7 6-benzyl-2-phenyl-2,6-diazaspiro[3.3]heptan-1-one 
• 960079-46-3 C₂₀H₂₂N₂O₂ 
• 960079-47-4 2-phenyl-2,6-diazaspiro[3.3]heptan-1-one 
• 959853-29-3 2-benzyl-6-phenyl-2,6-diazaspiro[3.3]heptane 
• 959853-27-1 C₁₉H₂₃ClN₂O 
• 959853-28-2 C₁₈H₂₀ClFN₂ 

Relevant articles and documents

AZETIDINES AS EP2 ANTAGONISTS

The present invention relates to a class of EP2 antagonistazetidinesof general formula (I), wherein the variables and substituents are as defined herein,and especially to EP2 antagonist compounds, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids (leiomyomata)and to intermediates usefulin their synthesis and to compositions containing them.

A novel rearrangement reaction conversion of 3-(chloromethyl)azetidin-2-ones to azetidine-3-carboxylic acid esters

Transformation of 3-(chloromethyl)azetidin-2-ones to azetidine-3-carboxylic acid esters is described. The readily available 3-(chloromethyl)azetidin-2-ones rearranged in good yields to azetidine-3-carboxylic acid esters on treatment with alkoxides. An alternative ring opening - ring closure procedure is also identified.