137266-59-2

Upstream product

• 813-99-0 3-chloro-(2,2-chloromethyl)propan-1-ol 
• 50547-79-0 3-chloro-2,2-dipropionyl chloride 
• 17831-70-8 3-chloro-2,2-bis(chloromethyl)propionic acid-1 
• 137606-01-0 N-benzyl-3-chloro-2,2-bis(chloromethyl)propanamide 
• 115-77-5 Pentaerythritol 

Downstream Products

• 137266-85-4 1-benzyl-3-chloromethylazetidine-3-carboxylic acid ethyl ester 
• 960079-40-7 6-benzyl-2-phenyl-2,6-diazaspiro[3.3]heptan-1-one 
• 960079-46-3 C₂₀H₂₂N₂O₂ 
• 960079-47-4 2-phenyl-2,6-diazaspiro[3.3]heptan-1-one 
• 959853-29-3 2-benzyl-6-phenyl-2,6-diazaspiro[3.3]heptane 
• 960079-48-5 1-benzyl-3-(chloromethyl)azetidine-3-carboxylic acid 
• 106014-95-3 N-benzyl-3-hydroxymethyl-azetidine-3-carboxylic acid 

Relevant academic research and scientific papers

AZETIDINES AS EP2 ANTAGONISTS

The present invention relates to a class of EP2 antagonistazetidinesof general formula (I), wherein the variables and substituents are as defined herein,and especially to EP2 antagonist compounds, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids (leiomyomata)and to intermediates usefulin their synthesis and to compositions containing them.

Concise synthesis of novel 2,6-diazaspiro[3.3]heptan-1-ones and their conversion into 2,6-diazaspiro[3.3]heptanes

A concise synthesis, amenable to library production of 2,6-diazaspiro[3.3] heptan-1-ones and their subsequent conversion into 2,6-diazaspiro[3.3]heptanes is reported. Georg Thieme Verlag Stuttgart.

A novel rearrangement reaction conversion of 3-(chloromethyl)azetidin-2-ones to azetidine-3-carboxylic acid esters

Transformation of 3-(chloromethyl)azetidin-2-ones to azetidine-3-carboxylic acid esters is described. The readily available 3-(chloromethyl)azetidin-2-ones rearranged in good yields to azetidine-3-carboxylic acid esters on treatment with alkoxides. An alternative ring opening - ring closure procedure is also identified.