3,3-dibromo-2-piperidone

Base Information

• Chemical Name: 3,3-dibromo-2-piperidone
• CAS No.: 26228-95-5
• Molecular Formula: C5H7Br2NO
• Molecular Weight: 256.925
• Mol file: 26228-95-5.mol

Synonyms:3,3-Dibromo-2-piperidinone;3,3-dibromo-2-piperidone;3,3-dibromopiperidin-2-one

Chemical Property of 3,3-dibromo-2-piperidone

Chemical Property:

• Melting Point: 170-171 °C
• Boiling Point: 330.6±42.0 °C(Predicted)
• PKA: 13.26±0.40(Predicted)
• PSA: 29.10000
• Density: 2.036±0.06 g/cm3(Predicted)
• LogP: 1.71130
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3,3-Dibromopiperidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3-dibromo-2-piperidone

There total 5 articles about 3,3-dibromo-2-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

piperidin-2-one (675-20-7) → 3,3-dibromopiperidin-2-one (26228-95-5)

Guidance literature:

With phosphorus pentachloride; bromine; zinc(II) chloride; In chloroform; for 5h; Ambient temperature;

Reference yield:

5-methoxycarbonylamino-valeric acid (756874-11-0) → 3,3-dibromopiperidin-2-one (26228-95-5)

Guidance literature:

With chloroform; bromine; phosphorus tribromide; unter Belichtung;

DOI:10.1021/ja01312a014

Reference yield:

5-aminopentanoic acid (660-88-8) → 3,3-dibromopiperidin-2-one (26228-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous alkali

2: phosphorus (III)-bromide; chloroform; bromine / unter Belichtung

With chloroform; bromine; phosphorus tribromide;

DOI:10.1021/ja01312a014

upstream raw materials:

piperidin-2-one

5-methoxycarbonylamino-valeric acid

5-aminopentanoic acid

3-bromo-2-piperidinone

Downstream raw materials:

(E)-3-bromo-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridine-2(1H)-one

(E)-3-bromo-1-(2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridine-2(1H)-one

(E)-3-bromo-1-(2-ethyl-3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridine-2(1H)-one

(E)-3-bromo-1-(2-propyl-3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridine-2(1H)-one

Refernces

• 1、 -. "Synthesis method of valerolactam alkaloid compound (by machine translation)". Paragraph 0029; 0042; 0050-0052. . Retrieved 2019/10/01.
• 2、 -. "PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF". Paragraph 0196-0198. . Retrieved 2019/12/05.