4-Phenylpyridine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 4-Phenylpyridine-2-carboxylic acid methyl ester
• CAS No.: 18714-17-5
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Hs Code.: 2933399090
• Mol file: 18714-17-5.mol

Synonyms:4-Phenylpyridine-2-carboxylic acid methyl ester;Methyl 4-phenylpicolinate

Chemical Property of 4-Phenylpyridine-2-carboxylic acid methyl ester

Chemical Property:

• PSA: 39.19000
• LogP: 2.53520

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-phenylpicolinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Phenylpyridine-2-carboxylic acid methyl ester

There total 19 articles about 4-Phenylpyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-iodopyridine-2-carboxylic acid methyl ester (380381-28-2) + phenylboronic acid (98-80-6) → methyl 4-phenylpyridine-2-carboylate (18714-17-5)

Guidance literature:

4-iodopyridine-2-carboxylic acid methyl ester; phenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 12h;

With sulfuric acid; In methanol; at 85 ℃; for 36h;

Reference yield: 73.2%

methyl 4-bromopyridine-2-carboxylate (29681-42-3) + phenylboronic acid (98-80-6) → methyl 4-phenylpyridine-2-carboylate (18714-17-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield: 71.0%

methanol (67-56-1) + 2-chloro-4-(phenyl)pyridine (42260-39-9) + carbon monoxide (201230-82-2) → methyl 4-phenylpyridine-2-carboylate (18714-17-5)

Guidance literature:

With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; at 70 ℃; under 30003 Torr;

upstream raw materials:

(E)-3-phenylpropenal

C₂₂H₂₀NO₂P

4-Chloro-pyridine-2-carboxylic acid methyl ester

phenylboronic acid

Downstream raw materials:

2-(hydroxymethyl)-4-phenylpyridine

C₁₇H₂₃NO₄

C₁₇H₂₃NO₄