Technology Process of 4-BroMo-2-cyanobenzoic Acid
There total 3 articles about 4-BroMo-2-cyanobenzoic Acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 4-bromo-2-cyanobenzoate;
With
lithium hydroxide monohydrate; water;
In
1,2-dimethoxyethane;
for 0.5h;
Cooling with ice;
With
hydrogenchloride;
In
1,2-dimethoxyethane; water;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium nitrite; sulfuric acid / water / 0.67 h / Cooling with ice
1.2: 2 h / 5 °C
2.1: 1-methyl-pyrrolidin-2-one / 1 h / 60 °C
3.1: lithium hydroxide monohydrate; water / 1,2-dimethoxyethane / 0.5 h / Cooling with ice
3.2: Cooling with ice
With
lithium hydroxide monohydrate; sulfuric acid; water; sodium nitrite;
In
1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1-methyl-pyrrolidin-2-one / 1 h / 60 °C
2.1: lithium hydroxide monohydrate; water / 1,2-dimethoxyethane / 0.5 h / Cooling with ice
2.2: Cooling with ice
With
lithium hydroxide monohydrate; water;
In
1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane;
