(3-Bromo-5-nitrophenyl)(morpholino)methanone

Base Information

• Chemical Name: (3-Bromo-5-nitrophenyl)(morpholino)methanone
• CAS No.: 941294-19-5
• Molecular Formula: C11H11BrN2O4
• Molecular Weight: 315.123
• Hs Code.: 2934999090
• Mol file: 941294-19-5.mol

Synonyms:(3-Bromo-5-nitrophenyl)(morpholino)methanone;N-(3-Bromo-5-nitrobenzoyl)morpholine;4-(3-Bromo-5-nitrobenzoyl)morpholine98%

Chemical Property of (3-Bromo-5-nitrophenyl)(morpholino)methanone

Chemical Property:

• PSA: 75.36000
• LogP: 2.29080
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

N-(3-Bromo-5-nitrobenzoyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-Bromo-5-nitrophenyl)(morpholino)methanone

There total 1 articles about (3-Bromo-5-nitrophenyl)(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 3-bromo-5-nitro-benzoic acid (6307-83-1) → (3-bromo-5-nitrophenyl)(morpholin-4-yl)methanone (941294-19-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

Reference yield:

(3-bromo-5-nitrophenyl)(morpholin-4-yl)methanone (941294-19-5) + phenylboronic acid (98-80-6) → morpholino-(5-nitro-[1,1'-biphenyl]-3-yl)methanone (1570262-20-2)

Guidance literature:

With palladium diacetate; sodium carbonate; tris-(o-tolyl)phosphine; In 1,2-dimethoxyethane; water; at 100 ℃; for 3h; Concentration;

Reference yield:

(3-bromo-5-nitrophenyl)(morpholin-4-yl)methanone (941294-19-5) → (5-amino-[1,1'-biphenyl]-3-yl)(morpholino)methanone (1570262-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane; water / 3 h / 100 °C

2: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate / 3 h / 20 °C

With palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium carbonate; acetic acid; tris-(o-tolyl)phosphine; In 1,2-dimethoxyethane; water; ethyl acetate;

upstream raw materials:

morpholine

3-bromo-5-nitro-benzoic acid

Downstream raw materials:

morpholino-(5-nitro-[1,1'-biphenyl]-3-yl)methanone

(5-amino-[1,1'-biphenyl]-3-yl)(morpholino)methanone

morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone

Refernces