morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone

Base Information

Chemical Name:morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone
CAS No.:1570255-74-1
Molecular Formula:C₂₂H₁₉F₃N₄O₂
Molecular Weight:428.414
Hs Code.:

Synonyms:morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone

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Chemical Property of morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone

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Technology Process of morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone

There total 4 articles about morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 1570255-74-1
morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 °C

2: sodium carbonate; palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane; water / 3 h / 100 °C

3: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate / 3 h / 20 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 0.5 h / 130 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; tris-(o-tolyl)phosphine; sodium t-butanolate; In 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1570262-22-4
(5-amino-[1,1'-biphenyl]-3-yl)(morpholino)methanone

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1570255-74-1
morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 941294-19-5
(3-bromo-5-nitrophenyl)(morpholin-4-yl)methanone

: 1570255-74-1
morpholin-4-yl(5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane; water / 3 h / 100 °C

2: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate / 3 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 0.5 h / 130 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; tris-(o-tolyl)phosphine; sodium t-butanolate; In 1,2-dimethoxyethane; water; ethyl acetate; toluene;