Methyl 5-aMino-3-chloropyridine-2-carboxylate

Base Information

• Chemical Name: Methyl 5-aMino-3-chloropyridine-2-carboxylate
• CAS No.: 1256825-20-3
• Molecular Formula: C₇H₇ClN₂O₂
• Molecular Weight: 186.598
• Hs Code.: 2933399090
• Mol file: 1256825-20-3.mol

Synonyms:Methyl 5-aMino-3-chloropyridine-2-carboxylate;Methyl 5-amino-3-chloropicolinate, 5-Amino-3-chloro-2-(methoxycarbonyl)pyridine;methyl 5-amino-3-chloropicolinate

Chemical Property of Methyl 5-aMino-3-chloropyridine-2-carboxylate

Chemical Property:

• Boiling Point: 368.1±37.0 °C(Predicted)
• PKA: 0.03±0.10(Predicted)
• PSA: 65.21000
• Density: 1.384±0.06 g/cm3(Predicted)
• LogP: 1.68500

Purity/Quality:

97% ^*data from raw suppliers

Methyl 5-amino-3-chloropyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-aMino-3-chloropyridine-2-carboxylate

There total 1 articles about Methyl 5-aMino-3-chloropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 6-bromo-5-chloropyridin-3-amine (130284-52-5) → 5-amino-3-chloro-2-pyridinecarboxylic acid methyl ester (1256825-20-3)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In toluene; at 70 ℃; under 1810.07 Torr;

Reference yield:

5-amino-3-chloro-2-pyridinecarboxylic acid methyl ester (1256825-20-3) → N-(5-chloro-6-(hydrazinecarbonyl)pyridin-3-yl)-1-(isoquinolin-4-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; trichlorophosphate / dichloromethane / 1 h / 20 °C

2: hydrazine hydrate / ethanol / 4 h / 80 °C

With pyridine; hydrazine hydrate; trichlorophosphate; In ethanol; dichloromethane;

Reference yield:

5-amino-3-chloro-2-pyridinecarboxylic acid methyl ester (1256825-20-3) → tert-butyl (6-acetyl-5-chloropyridin-3-yl)carbamate

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 70 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 3 h / 0 - 20 °C

3.1: tetrahydrofuran / 3 h / -30 - 20 °C

With dmap; water; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran;

upstream raw materials:

methanol

carbon monoxide

6-bromo-5-chloropyridin-3-amine

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