4-[(4-Fluorobenzyl)oxy]piperidine hydrochloride

Base Information

• Chemical Name: 4-[(4-Fluorobenzyl)oxy]piperidine hydrochloride
• CAS No.: 1185107-71-4
• Molecular Formula: C12H17ClFNO
• Molecular Weight: 245.7208832
• Hs Code.: 2933399990
• Mol file: 1185107-71-4.mol

Synonyms:4-[(4-Fluorobenzyl)oxy]piperidine hydrochloride;4-(5-Fluoro-benzyloxy)-piperidinehydrochloride

Chemical Property of 4-[(4-Fluorobenzyl)oxy]piperidine hydrochloride

Chemical Property:

• PSA: 21.26000
• LogP: 3.22510
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-((4-Fluorobenzyl)oxy)piperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-[(4-Fluorobenzyl)oxy]piperidine hydrochloride

There total 3 articles about 4-[(4-Fluorobenzyl)oxy]piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-((4-fluorobenzyl)oxy)piperidine-1-carboxylate (1121587-29-8) → C12H16FNO*ClH (1185107-71-4)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/acs.jmedchem.6b01033

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → C12H16FNO*ClH (1185107-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2: hydrogenchloride / dichloromethane; methanol / 12 h / 20 °C

With hydrogenchloride; sodium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/acs.jmedchem.6b01033

Reference yield:

4-Fluorobenzyl bromide (459-46-1) → C12H16FNO*ClH (1185107-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2: hydrogenchloride / dichloromethane; methanol / 12 h / 20 °C

With hydrogenchloride; sodium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/acs.jmedchem.6b01033

upstream raw materials:

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-((4-fluorobenzyl)oxy)piperidine-1-carboxylate

4-Fluorobenzyl bromide

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