2-(4-(Hydroxymethyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

Base Information

• Chemical Name: 2-(4-(Hydroxymethyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
• CAS No.: 1072960-82-7
• Molecular Formula: C12H14BNO5
• Molecular Weight: 263.058
• Mol file: 1072960-82-7.mol

Synonyms:2-(4-(Hydroxymethyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione;4-(Hydroxymethyl)phenylboronic acid MIDA ester

Chemical Property of 2-(4-(Hydroxymethyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

Chemical Property:

• Melting Point: 169-179 °C
• PSA: 76.07000
• LogP: -1.15620

Purity/Quality:

97% ^*data from raw suppliers

4-(Hydroxymethyl)phenylboronic acid MIDA ester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-(Hydroxymethyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

There total 5 articles about 2-(4-(Hydroxymethyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-methyliminodiacetic acid (4408-64-4) + p-hydroxymethylphenylboronic acid (59016-93-2) → 4-(hydroxymethyl)phenylboronic acid MIDA ester (1072960-82-7)

Guidance literature:

In benzene; for 20h; Dean-Stark; Reflux;

DOI:10.1055/s-0040-1707194

Reference yield: 83.0%

(C(CH3)3Si(CH3)2OCH2C6H4)BN(CH3)(CH2CO2)2 (1072960-69-0) → 4-(hydroxymethyl)phenylboronic acid MIDA ester (1072960-82-7)

Guidance literature:

With pyridine hydrogenfluoride; In tetrahydrofuran; at 23 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/ja8063759

Reference yield: 79.0%

N-methyliminodiacetic acid boronate (1072960-68-9) → 4-(hydroxymethyl)phenylboronic acid MIDA ester (1072960-82-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; DDQ, CH2Cl2, 23°C, 1.5 h;

DOI:10.1021/ja8063759

upstream raw materials:

sodium tetrahydroborate

4-formylphenylboronic acid

N-methyliminodiacetic acid boronate

(C(CH₃)3Si(CH₃)2OCH₂C₆H₄)BN(CH₃)(CH₂CO₂)2

Downstream raw materials:

(ICH₂C₆H₄)BN(CH₃)(CH₂CO₂)2

4-carboxyphenyl boronic acid MIDA ester

(C(CH₃)3Si(CH₃)2OCH₂C₆H₄)BN(CH₃)(CH₂CO₂)2

N-methyliminodiacetic acid boronate