4-formylphenylboronic acid

Base Information

• Chemical Name: 4-formylphenylboronic acid
• CAS No.: 1072960-66-7
• Molecular Formula: C₁₂H₁₂BNO₅
• Molecular Weight: 261.042
• Mol file: 1072960-66-7.mol

Synonyms:4-formylphenylboronic acid

Chemical Property of 4-formylphenylboronic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-formylphenylboronic acid

There total 4 articles about 4-formylphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(hydroxymethyl)phenylboronic acid MIDA ester (1072960-82-7) → 4-formylphenylboronic acid (1072960-66-7)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; COCl2, DMSO, CH2Cl2, triethylamine;

DOI:10.1021/ja8063759

Reference yield: 86.0%

N-methyliminodiacetic acid (4408-64-4) + 4-formylphenylboronic acid, (87199-17-5) → 4-formylphenylboronic acid (1072960-66-7)

Guidance literature:

In dimethyl sulfoxide; toluene; for 3h; Reflux; Inert atmosphere;

DOI:10.1021/ja8063759

Reference yield: 63.0%

4-formylphenylboronic acid, (87199-17-5) + (N-methylimino)diacetic acid anhydride (13480-36-9) → 4-formylphenylboronic acid (1072960-66-7)

Guidance literature:

In 1,4-dioxane; at 70 ℃; for 24h; Dean-Stark;

DOI:10.1021/acs.orglett.0c02449

upstream raw materials:

4-(hydroxymethyl)phenylboronic acid MIDA ester

N-methyliminodiacetic acid

4-formylphenylboronic acid,

(N-methylimino)diacetic acid anhydride

Downstream raw materials:

(OC₄H₈NCH₂C₆H₄)BN(CH₃)(CH₂CO₂)2

4-(hydroxymethyl)phenylboronic acid MIDA ester

(ICHCHC₆H₄)BN(CH₃)(CH₂CO₂)2

(C₂H₅OCOCHCHC₆H₄)BN(CH₃)(CH₂CO₂)2

Refernces

• 1、 -. "Synthesis of Benzimidazoles bearing borionic acid functionality via metal-free aerobic oxidation". Paragraph 0226-0028. . Retrieved 2017/02/24.
• 2、 -. "Synthetic Method of Benzimidazole via Aerobic Oxidation". Paragraph 0214. . Retrieved 2016/11/14.