(2,4-Difluorophenyl)trimethylsilane

Base Information

• Chemical Name: (2,4-Difluorophenyl)trimethylsilane
• CAS No.: 148854-10-8
• Molecular Formula: C₉H₁₂F₂Si
• Molecular Weight: 186.277
• DSSTox Substance ID: DTXSID001282178
• Nikkaji Number: J753.943F
• Mol file: 148854-10-8.mol

Synonyms:(2,4-Difluorophenyl)trimethylsilane;148854-10-8;Benzene, 2,4-difluoro-1-(trimethylsilyl)-;(2,4-difluorophenyl)-trimethylsilane;MFCD22682801;C9H12F2Si;DTXSID001282178;YFA85410;AC7740;AKOS027256878;2,4-Difluoro-1-(trimethylsilyl)benzene;AS-64920;SY022240;CS-0320904

Chemical Property of (2,4-Difluorophenyl)trimethylsilane

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 186.06763324
• Heavy Atom Count: 12
• Complexity: 153

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)C1=C(C=C(C=C1)F)F

Technology Process of (2,4-Difluorophenyl)trimethylsilane

There total 2 articles about (2,4-Difluorophenyl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,1,1,2,2,2-hexamethyldisilane (1450-14-2) + 2,4-difluorobromobenzene (348-57-2) → (2,4-difluorophenyl)trimethylsilane (148854-10-8)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 160 ℃; for 96h;

DOI:10.1016/0022-328X(93)80045-D

Reference yield: 91.0%

chloro-trimethyl-silane (75-77-4) + 2,4-difluorobromobenzene (348-57-2) → (2,4-difluorophenyl)trimethylsilane (148854-10-8)

Guidance literature:

2,4-difluorobromobenzene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -75 ℃; for 0.25h;

chloro-trimethyl-silane; In tetrahydrofuran; pentane;

DOI:10.1002/ejoc.200600589

Reference yield: 88.0%

carbon dioxide (124-38-9,18923-20-1) + (2,4-difluorophenyl)trimethylsilane (148854-10-8) → 2,6-difluoro-3-(trimethylsilyl)benzoic acid

Guidance literature:

(2,4-difluorophenyl)trimethylsilane; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -75 ℃; for 0.75h;

carbon dioxide; In tetrahydrofuran; cyclohexane; at -75 - 25 ℃;

DOI:10.1002/ejoc.200600589

upstream raw materials:

1,1,1,2,2,2-hexamethyldisilane

2,4-difluorobromobenzene

chloro-trimethyl-silane

Downstream raw materials:

1,2,4-trifluorobenzene

2,4-difluorobromobenzene

1,5-difluoro-2,4-dinitrobenzene

2,4-Difluoronitrobenzene