3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

Base Information

• Chemical Name: 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone
• CAS No.: 1402830-75-4
• Molecular Formula: C25H19NO3
• Molecular Weight: 381.42326
• Mol file: 1402830-75-4.mol

Synonyms:3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone;3-[3-(4-Methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone

Chemical Property of 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

Chemical Property:

• Storage Temp.: ?20°C
• Solubility.: DMSO: soluble20mg/mL, clear

Purity/Quality:

97% ^*data from raw suppliers

Ceranib-2 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

• Description: Ceranib-2 is a ceramidase inhibitor that inhibits ceramidase activity (IC50 = 28 μM in SKOV3 cells). It also increases intracellular accumulation of various ceramides, including C14 ceramide , C24 ceramide , C26 ceramide, and C26:1 ceramide, and total ceramide levels and decreases levels of dihydrosphingosine, sphingosine, and sphingosine-1-phosphate in SKOV3 cells. In vivo, ceranib-2 (20 and 50 mg/kg, i.p.) reduces tumor volume in a JC mammary adenocarcinoma mouse syngeneic tumor model.

Technology Process of 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

There total 2 articles about 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-methoxy-benzaldehyde (123-11-5) + 3-acetyl-4-phenyl-1,2-dihydroquinolin-2-one (313273-62-0) → (E)-3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one (1402830-75-4)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 0 ℃; Reflux;

DOI:10.1002/jhet.2192

Reference yield:

(2-aminophenyl)(phenyl)methanone (2835-77-0) → (E)-3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one (1402830-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 1.5 h / 120 °C / Microwave irradiation

2.1: potassium hydroxide / water; ethanol / 0.75 h / 0 °C

2.2: 0 - 20 °C

With potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.9b01526

upstream raw materials:

4-methoxy-benzaldehyde

3-acetyl-4-phenyl-1,2-dihydroquinolin-2-one

(2-aminophenyl)(phenyl)methanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1402830-75-4 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

Send

Send

Metric Ton KG G Pound L ML

Send

Send