Azetidin-3-yl-acetic acid methyl ester hydrochloride

Base Information

• Chemical Name: Azetidin-3-yl-acetic acid methyl ester hydrochloride
• CAS No.: 1229705-59-2
• Molecular Formula: C6H12ClNO2
• Molecular Weight: 165.61798
• Hs Code.: 2933990090
• Mol file: 1229705-59-2.mol

Synonyms:Azetidin-3-yl-acetic acid methyl ester hydrochloride;3-Azetidineacetic acid methyl ester HCl

Chemical Property of Azetidin-3-yl-acetic acid methyl ester hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 0.89970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3-AzetidineaceticAcidMethylEsterHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Azetidin-3-yl-acetic acid methyl ester hydrochloride

There total 2 articles about Azetidin-3-yl-acetic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methanol (67-56-1) + 2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid (183062-96-6) → azetidin-3-yl-acetic acid methyl ester hydrochloride salt (1229705-59-2)

Guidance literature:

With acetyl chloride; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2010.02.029

Reference yield:

tert-butyl 3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate (497160-14-2) → azetidin-3-yl-acetic acid methyl ester hydrochloride salt (1229705-59-2)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 25 ℃; for 2h;

Reference yield: 27.0%

azetidin-3-yl-acetic acid methyl ester hydrochloride salt (1229705-59-2) + 4,4-diphenyl-3-butenyl bromide (6078-95-1) → methyl 1-(4,4-diphenylbut-3-en-1-yl)azetidin-3-ylacetate (1229705-66-1)

Guidance literature:

With potassium carbonate; sodium iodide; In 1,2-dimethoxyethane; at 20 ℃; for 120h; Inert atmosphere; Darkness;

DOI:10.1016/j.ejmech.2010.02.029

upstream raw materials:

methanol

2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid

tert-butyl 3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate

Downstream raw materials:

methyl 1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}azetidin-3-yl-acetate

methyl 1-(4,4-diphenylbut-3-en-1-yl)azetidin-3-ylacetate

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