2-AMino-4-fluoro-5-hydroxy-benzoic acid Methyl ester

Base Information

Chemical Name:2-AMino-4-fluoro-5-hydroxy-benzoic acid Methyl ester
CAS No.:1113049-61-8
Molecular Formula:C8H8FNO3
Molecular Weight:185.155
Hs Code.:
Mol file:1113049-61-8.mol

Synonyms:2-AMino-4-fluoro-5-hydroxy-benzoic acid Methyl ester;methyl 2-amino-4-fluoro-5-hydroxybenzoate

Suppliers and Price of 2-AMino-4-fluoro-5-hydroxy-benzoic acid Methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl2-Amino-4-fluoro-5-hydroxybenzoate
50mg
$ 220.00

Crysdot
Methyl2-amino-4-fluoro-5-hydroxybenzoate 95+%
1g
$ 640.00

Chemenu
Methyl2-amino-4-fluoro-5-hydroxybenzoate 95%
1g
$ 598.00

Chemcia Scientific
2-Amino-4-fluoro-5-hydroxy-benzoicacidmethylester ＞97%
2.5 G
$ 1195.00

AK Scientific
Methyl2-amino-4-fluoro-5-hydroxybenzoate
10g
$ 7162.00

AK Scientific
Methyl2-amino-4-fluoro-5-hydroxybenzoate
2.5g
$ 1953.00

Total 4 raw suppliers

Chemical Property of 2-AMino-4-fluoro-5-hydroxy-benzoic acid Methyl ester

Chemical Property:

Boiling Point:344.1±42.0 °C(Predicted)
PKA:8.17±0.23(Predicted)
PSA：72.55000
Density:1.400±0.06 g/cm3(Predicted)
LogP:1.48130

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-Amino-4-fluoro-5-hydroxybenzoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-AMino-4-fluoro-5-hydroxy-benzoic acid Methyl ester

There total 3 articles about 2-AMino-4-fluoro-5-hydroxy-benzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 67-56-1
methanol

: 1113049-59-4
5-(benzyloxy)-4-fluoro-2-nitrobenzoic acid

: 1113049-61-8
methyl 2-amino-4-fluoro-5-hydroxybenzoate

Guidance literature:: methanol; C₁₄H₁₀FNO₅; With sulfuric acid; Reflux;

With palladium 10% on activated carbon; hydrogen; at 20 ℃; under 760.051 Torr;
DOI:10.1016/j.bmcl.2013.05.037

Reference yield:

: 1113049-60-7
methyl 5-(benzyloxy)-4-fluoro-2-nitrobenzoate

: 1113049-61-8
methyl 2-amino-4-fluoro-5-hydroxybenzoate

Guidance literature:: With hydrogen; 10 % Pd(OH)2/C; In methanol; ethyl acetate; at 20 ℃; under 1551.49 Torr;

Reference yield:

: 20372-63-8
4,5-difluoro-2-nitrobenzoic acid

: 1113049-61-8
methyl 2-amino-4-fluoro-5-hydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide

2.1: sulfuric acid / Reflux

2.2: 20 °C / 760.05 Torr

With sulfuric acid; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.05.037