5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

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Chemical Name:5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid
CAS No.:1402141-72-3
Molecular Formula:C₃₈H₃₅ClF₄N₄O₆S₂
Molecular Weight:819.298
Hs Code.:

5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

Synonyms:5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

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Chemical Property of 5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

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Technology Process of 5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

There total 5 articles about 5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402141-66-5
ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate

: 1402141-72-3
5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 80 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane; ethanol; water / 20 h / Reflux; Inert atmosphere

2.2: Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

4.1: pyridine; aniline / 0 - 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; aniline; L-proline; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 1.1: |Ullmann Condensation;
DOI:10.1021/jm3010306

Reference yield:

: 1384513-05-6
ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

: 1402141-72-3
5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 6 h / 20 °C

2.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 80 °C / Inert atmosphere

3.1: sodium hydroxide / 1,4-dioxane; ethanol; water / 20 h / Reflux; Inert atmosphere

3.2: Inert atmosphere

4.1: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

5.1: pyridine; aniline / 0 - 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; aniline; L-proline; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 2.1: |Ullmann Condensation;
DOI:10.1021/jm3010306

Reference yield:

: 1402141-68-7
ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate

: 1402141-72-3
5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / 1,4-dioxane; ethanol; water / 20 h / Reflux; Inert atmosphere

1.2: Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

3.1: pyridine; aniline / 0 - 20 °C / Inert atmosphere

With pyridine; palladium on activated charcoal; hydrogen; aniline; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water;
DOI:10.1021/jm3010306