Benzeneacetonitrile, 2-fluoro-alpha-hydroxy-, (alphaS)- (9CI)

Base Information

Chemical Name:Benzeneacetonitrile, 2-fluoro-alpha-hydroxy-, (alphaS)- (9CI)
CAS No.:485759-27-1
Molecular Formula:C₈H₆FNO
Molecular Weight:151.14
Hs Code.:
Mol file:485759-27-1.mol

Synonyms:Benzeneacetonitrile, 2-fluoro-alpha-hydroxy-, (alphaS)- (9CI)

Suppliers and Price of Benzeneacetonitrile, 2-fluoro-alpha-hydroxy-, (alphaS)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Benzeneacetonitrile, 2-fluoro-alpha-hydroxy-, (alphaS)- (9CI)

Chemical Property:

Purity/Quality:: 99%+ ^*data from raw suppliers

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Technology Process of Benzeneacetonitrile, 2-fluoro-alpha-hydroxy-, (alphaS)- (9CI)

There total 16 articles about Benzeneacetonitrile, 2-fluoro-alpha-hydroxy-, (alphaS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 7677-24-9
trimethylsilyl cyanide

: 446-52-6
2-Fluorobenzaldehyde

: 290374-44-6,485759-27-1
(R)-2-hydroxy-2-(2-fluorophenyl)acetonitrile

Guidance literature:: trimethylsilyl cyanide; With methanol; C₆₀H₄₈LiN₂O₄P₂Ru⁽¹⁺⁾*Cl^(1-); Inert atmosphere; Cooling;

2-Fluorobenzaldehyde; In tert-butyl methyl ether; at -78 ℃; for 18h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol200187d

Reference yield:

: 773837-37-9
sodium cyanide

: 446-52-6
2-Fluorobenzaldehyde

: 133721-88-7,485759-27-1
(+/-)-2-hydroxy-2-(2-fluorophenyl)acetonitrile

Guidance literature:: 2-Fluorobenzaldehyde; With sodium hydrogensulfite; In diethyl ether; water; at 20 ℃; for 2h;

sodium cyanide; In diethyl ether; water; at 20 ℃;
DOI:10.1016/j.tetlet.2008.08.090