Depo-Testosterone

Base Information

• Chemical Name: Depo-Testosterone
• CAS No.: 58-20-8
• Molecular Formula: C27H40O3
• Molecular Weight: 412.613
• Hs Code.: 2937290000
• NSC Number: 9157
• Mol file: 58-20-8.mol

Synonyms:Andronate;Depo-Testosterone;Depo-Testosterone Cypionate;deposteron;Depostomead;Duratest;Testa-C;Testex Elmu;testosterone 17 beta-cyclopentanepropionate;testosterone 17 beta-cyclopentylpropionate;testosterone 17 beta-cypionate;testosterone cypionate

Chemical Property of Depo-Testosterone

Chemical Property:

• Appearance/Colour: white to off-white crystalline powder
• Vapor Pressure: 3.78E-11mmHg at 25°C
• Melting Point: 98 - 104ºC
• Refractive Index: 1.546
• Boiling Point: 525.9 °C at 760 mmHg
• Flash Point: 223.9 °C
• PSA: 43.37000
• Density: 1.1 g/cm³
• LogP: 6.40050
• Storage Temp.: 2-8°C
• XLogP3: 6.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 412.29774513
• Heavy Atom Count: 30
• Complexity: 732

Purity/Quality:

99.9% ^*data from raw suppliers

Testosterone cypionate United States Pharmacopeia (USP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 45-63
• Safety Statements: 53-22-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=CC(=O)CCC35C
• Characteristics: Testosterone cypionate has greater lipid solubility due to esterification, which delays its release into the circulation and prolongs its action. It exhibits anabolic activity and reduced androgenicity, making it popular among recreational athletes and bodybuilders.; Abuse of testosterone cypionate can lead to various mental and physical health issues, including mood disorders, dependency syndromes, pulmonary embolism, and cardiovascular alterations.
• Mechanism of Action: Once in the bloodstream, the ester is removed, leaving free (active) testosterone, which acts through androgen receptors.
• Pharmacokinetics: The half-life of testosterone cypionate is approximately 8 days after injection.
• Medical Uses: Treatment of delayed puberty, male climacteric, specific types of anemia, erectile dysfunction due to kidney failure, hormone replacement therapy in men with hypogonadism, and as a secondary treatment for inoperable metastatic breast cancer in women.
• Historical Development: First synthesized in 1951 and introduced for medical use in the United States the same year under the brand name Depo-Testosterone. Initially used for various applications such as bone structural maturation, treating menorrhagia, excessive breastfeeding, increasing muscle mass, and combating osteoporosis. Over time, its use has primarily focused on male androgen deficiency.; FDA-approved for hormone replacement therapy in men with conditions related to endogenous testosterone deficiency and as a secondary treatment for inoperable metastatic breast cancer in women.

Technology Process of Depo-Testosterone

There total 8 articles about Depo-Testosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

cyclopentanepropanoyl chloride (104-97-2) + testosterone (58-22-0) → testosterone cypionate (58-20-8)

Guidance literature:

With pyridine; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 5h; Inert atmosphere;

Reference yield:

3-cyclopentylpropionic acid (140-77-2) → testosterone cypionate (58-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid anhydride

With acetic anhydride;

DOI:10.1021/ja01099a040

Reference yield:

3-ethoxy-17β-(3-cyclopentyl-propionyloxy)-androsta-3,5-diene (56736-66-4) → testosterone cypionate (58-20-8)

Guidance literature:

With hydrogenchloride; acetone;

DOI:10.1021/ja01099a040

upstream raw materials:

cyclopentanepropanoyl chloride

testosterone

3-cyclopentyl-propionic acid-anhydride

3-ethoxy-17β-(3-cyclopentyl-propionyloxy)-androsta-3,5-diene

Downstream raw materials:

testosterone

Refernces