Technology Process of Decoquinate
There total 6 articles about Decoquinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-[(4-decyloxy-3-ethoxy-phenylamino)-methylene]-malonic acid diethyl ester;
With
trichlorophosphate;
for 4h;
Reflux;
With
acetic acid;
for 7h;
Reflux;
DOI:10.1080/00397910903029891
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
1.2: 5 h / 20 °C / pH 7 - 8
2.1: sodium hydroxide; sodium dithionite / water / 85 - 90 °C
2.2: 1 h / 20 °C / pH 5 - 7
3.1: methanol / 5 h / 90 - 100 °C
4.1: potassium carbonate / Reflux
5.1: iron(III) oxide; Sulfate; sodium hydrogen sulfate / N,N-dimethyl-formamide / 4 h / 150 °C
With
hydrogenchloride; methanol; iron(III) oxide; sodium hydrogen sulfate; sodium dithionite; Sulfate; potassium carbonate; sodium hydroxide; sodium nitrite;
In
water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; sodium dithionite / water / 85 - 90 °C
1.2: 1 h / 20 °C / pH 5 - 7
2.1: methanol / 5 h / 90 - 100 °C
3.1: potassium carbonate / Reflux
4.1: iron(III) oxide; Sulfate; sodium hydrogen sulfate / N,N-dimethyl-formamide / 4 h / 150 °C
With
methanol; iron(III) oxide; sodium hydrogen sulfate; sodium dithionite; Sulfate; potassium carbonate; sodium hydroxide;
In
water; N,N-dimethyl-formamide;
