26692-07-9

Usage

Uses

Used in Organic Chemistry:
Diethyl (4-decyloxy-3-ethoxyanilino)methylenemalonate is used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure, including the long alkyl chain and aniline group, allows it to participate in a range of chemical reactions, making it a valuable building block in organic synthesis.
Used in Medicinal Chemistry:
Diethyl (4-decyloxy-3-ethoxyanilino)methylenemalonate is used as a potential pharmaceutical candidate due to its structural features. The presence of the long alkyl chain and aniline group may contribute to its interaction with biological targets, such as enzymes or receptors, and its potential biological activity. Further research and testing would be required to explore its therapeutic potential and develop it into a drug candidate.
Used in Drug Delivery Systems:
Diethyl (4-decyloxy-3-ethoxyanilino)methylenemalonate could be used in the development of drug delivery systems, where its unique structure may facilitate the encapsulation, solubility, or targeted delivery of therapeutic agents. Its properties may be harnessed to improve the bioavailability, stability, or efficacy of drugs, making it a promising component in the design of advanced drug delivery platforms.
Used in Material Science:
The structural features of diethyl (4-decyloxy-3-ethoxyanilino)methylenemalonate may also find applications in material science, where it could be used to develop new materials with specific properties. Its long alkyl chain and aniline group could contribute to the formation of self-assembling structures, polymers, or other materials with potential uses in various industries, such as coatings, adhesives, or sensors.

Upstream product

• 1216638-27-5 4-decyloxy-3-ethoxyaniline hydrochloride 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 94-71-3 2-Ethoxyphenol 
• 55483-70-0 3-ethoxy-4-hydroxyaniline 
• 88331-63-9 2-ethoxy-4-nitroso-phenol 
• 112-29-8 1-bromo dodecane 
• 55483-71-1 3-Ethoxy-4-hydroxy-anilinomethylenmalonsaeurediethylester 
• 55483-78-8 4-(decyloxy)-3-ethoxybenzenamine 

Downstream Products

• 18507-89-6 decoquinate 

Relevant academic research and scientific papers

Synthetic method of decoquinate

The invention discloses a synthetic method of decoquinate, and belongs to the technical field of pharmaceutical engineering. The synthetic method takes o-hydroxyphenyl ethyl ether as a raw material to prepare decoquinate via the processes of coupling, reduction, condensation, etherification, cyclization and the like. The process of reduction in the method adopts environment-friendly hydrazine hydrate as a reducer to reduce an azo-compound and introduce an amino group, so that the synthetic method is good in selectivity, and environmentally friendly, and beneficial for reducing environmental pollution problems; BTC is adopted as a cyclization reagent in the process of cyclization, so that the condition is mild, the requirement on equipment is lowered, and the cost is reduced.

Preparation method of decoquinate

The invention discloses a preparation method of decoquinate. Industrialized 2-hydroxyphenylacetic acid phenetole serves as starting materials, and a product with better quality is obtained through diazo coupling, sodium dithionite reduction, condensation, etherificationa and superstrong solid acid SO4/Fe2O3 and sodium bisulfate cyclization. Part intermediate of a synthetic route of the decoquinate does not need to be purified, used solvent is single, aftertreatment of the intermediate and use of organic solvent are reduced, the cost is reduced, the whole process route is short, extremely high temperature or highly corrosive liquid acid is not needed, requirement to equipment is low, operation is easy and convenient, the production cycle is short, produced three wastes are fewer, the production yield is high, the quality is good, and the preparation method of the decoquinate is suitable for industrial production.

Synthesis and anticoccidial activities of Quinoline Carboxylate derivatives with Methyl (E)-2-(3-methoxy)acrylate moiety

A series of novel quinoline carboxylate derivatives with methyl (E)-2-(3-methoxy) acrylate group were designed and synthesized as anticoccidial medicines. The structures were confirmed by 1H NMR, IR and HR-MS spectra. The biological activities were primarily evaluated according to the anticoccidial index method. The results indicated that these compounds (7c, 7d, 7e, 7g) exhibited anticoccidial activities against Eimeria tenella. In particular, the anticoccidial index of 6-decyloxy-7-ethoxy-4-{6-[2-(2-methoxy-1-methoxycarbonyl- vinyl)phenoxy]pyrimidin-4-yloxy}- quinoline-3-carboxylic acid ethyl ester (7e) was 168.7, which indicated that the compound has a good anticoccidial activity.

Convenient and efficient preparation of ethyl 6-n-decyloxy-7-ethoxy-4- hydroxyquinoline-3-carboxylate

Ethyl 6-N-decyloxy-7-ethoxy-4-hydroxyquinoline-3-carboxylate has been synthesized from pyrocatechol in six steps and in 39.3% overall yield.

Efficient and practical synthesis of dissymmetrical ethers of 4-nitrocatechol

An efficient and practical synthesis of dissymmetrical ethers of 4-nitrocatechol from 5-nitrosalicyladehyde and 2-hydroxy-5-nitroacetophenone via Baeyer-Villiger oxidation is described. These dissymmetrical ethers are useful in the synthesis of various coccidiostats and other important pharmaceutical intermediates. Copyright Taylor & Francis Group, LLC.