methyl 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylate

Base Information

• Chemical Name: methyl 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylate
• CAS No.: 1227594-40-2
• Molecular Formula: C₈H₅ClF₃NO₂
• Molecular Weight: 239.581
• Hs Code.: 2933399990
• Mol file: 1227594-40-2.mol

Synonyms:methyl 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylate;Methyl 2-chloro-6-(trifluoromethyl)isonicotinate

Chemical Property of methyl 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylate

Chemical Property:

• PSA: 39.19000
• LogP: 2.54040
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Chloro-6-(trifluoromethyl)isonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylate

There total 1 articles about methyl 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylic acid (796090-23-8) → methyl 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylate (1227594-40-2)

Guidance literature:

With sulfuric acid; at 65 ℃;

Reference yield:

methyl 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylate (1227594-40-2) → methyl 2-(cyanomethyl)-6-(trifluoromethyl)pyridine-4-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium carbonate / dimethyl sulfoxide / 20 - 90 °C

2: water; sodium chloride / dimethyl sulfoxide / 4 h / 95 °C

With tetrabutylammomium bromide; water; potassium carbonate; sodium chloride; In dimethyl sulfoxide;

upstream raw materials:

methanol

2-chloro-6-(trifluoromethyl)pyridine-4-carboxylic acid