2,3-dihydro-N-(4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:2,3-dihydro-N-(4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide
CAS No.:1552280-87-1
Molecular Formula:C18H17N3O3
Molecular Weight:323.351
Hs Code.:
Mol file:1552280-87-1.mol

Synonyms:2,3-dihydro-N-(4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Suppliers and Price of 2,3-dihydro-N-(4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 2,3-dihydro-N-(4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Chemical Property:

PSA：76.26000
LogP:2.51530

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2,3-dihydro-N-(4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

There total 2 articles about 2,3-dihydro-N-(4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 83-10-3
antipyric acid

: 123-30-8
4-amino-phenol

: 1552280-87-1
N-(4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1552280-87-1
N-(4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium formate; palladium 10% on activated carbon / water; tetrahydrofuran / 24 h / 50 °C

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 46 °C

With 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; potassium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water;